A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University and the Broad Institute of MIT and Harvard has created the first high-resolution 4-D map of genome folding, tracking an ...
Biotechnology
Oct 6, 2017
0
363
New insights into the process of DNA looping have changed old perspectives about how the genome is organized within cells. Discoveries by IMP researchers have now elucidated a fundamental mechanism of life and settle a decade-long ...
Biotechnology
Nov 22, 2019
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420
Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology ...
Cell & Microbiology
Mar 29, 2023
0
64
Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, 'silence' one X chromosome. Their new study, published in Molecular ...
Cell & Microbiology
Mar 15, 2021
0
29
A molecular "motor" that organizes the genome into distinct neighborhoods by forming loops of DNA has been characterized by researchers at MIT and the Pasteur Institute in France.
Cell & Microbiology
Sep 29, 2017
1
16
In recent years, it has become evident that the spatial organisation of the genome is key for its function. This depends on a number of factors, including the cohesin protein complex. This essential complex is present in ...
Cell & Microbiology
Jun 5, 2018
0
62
Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified cohesin in vertebrates, a protein that is essential in cell division. Losada has studied cohesin since she identified it ...
Cell & Microbiology
Aug 11, 2020
0
7
We finally know why our DNA has an X shape. This finding by researchers at the Netherlands Cancer Institute may have much broader implications for how our cells behave. "It looks like we have uncovered a universal mechanism ...
Cell & Microbiology
Apr 20, 2023
0
29
We need a variety of antibody types to help fight off invading foreign pathogens and our genome is exquisitely tuned to produce them to meet emerging needs. A new study finds that not just our DNA, but its configuration and ...
Cell & Microbiology
Nov 19, 2020
0
30
Gene regulation relies on complex structural arrangements and processes at the molecular level. One of them, called 'chromatin loop extrusion', strikingly resembles the quick-lacing system of some trail running shoes: as ...
Cell & Microbiology
Dec 14, 2017
0
7
