X-file cracked: Mini-key determines DNA shape

We finally know why our DNA has an X shape. This finding by researchers at the Netherlands Cancer Institute may have much broader implications for how our cells behave. "It looks like we have uncovered a universal mechanism ...

Cohesin opens up for cell division

Scientists at Nagoya University, with colleagues at Kyoto University in Japan, have uncovered a mechanism that allows a protein complex to bind to DNA without impeding some of the important processes of cell division. Their ...

Study reveals new clues about the architecture of X chromosomes

Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, 'silence' one X chromosome. Their new study, published in Molecular ...

Chromatin regulation enables generation of diverse antibodies

We need a variety of antibody types to help fight off invading foreign pathogens and our genome is exquisitely tuned to produce them to meet emerging needs. A new study finds that not just our DNA, but its configuration and ...

Researchers map human genome in 4-D as it folds

A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University and the Broad Institute of MIT and Harvard has created the first high-resolution 4-D map of genome folding, tracking an ...

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