In recent years, it has become evident that the spatial organisation of the genome is key for its function. This depends on a number of factors, including the cohesin protein complex. This essential complex is present in ...
Cell & Microbiology
Jun 5, 2018
0
62
Gene regulation relies on complex structural arrangements and processes at the molecular level. One of them, called 'chromatin loop extrusion', strikingly resembles the quick-lacing system of some trail running shoes: as ...
Cell & Microbiology
Dec 14, 2017
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7
A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University and the Broad Institute of MIT and Harvard has created the first high-resolution 4-D map of genome folding, tracking an ...
Biotechnology
Oct 6, 2017
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363
A molecular "motor" that organizes the genome into distinct neighborhoods by forming loops of DNA has been characterized by researchers at MIT and the Pasteur Institute in France.
Cell & Microbiology
Sep 29, 2017
1
16
Twenty years ago, the protein complex cohesin was first described by researchers at the IMP. They found that its shape strikingly corresponds to its function: when a cell divides, the ring-shaped structure of cohesin keeps ...
Biotechnology
Apr 20, 2017
0
2
