Groundbreaking research by Sarah Hainer, an assistant professor of gene expression and cell fate in the University of Pittsburgh Department of Biological Sciences, and Thomas G. Fazzio of the University of Massachusetts Medical ...
Cell & Microbiology
Apr 8, 2019
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Toggling the functions of a protein that regulates gene expression during cellular reprogramming ensures cell fate conversion, an A*STAR study has found.
Cell & Microbiology
Nov 16, 2018
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The development of an adult organism starts with a fertilized egg that differentiates into hundreds of specialized cell types comprising tissues and organs. How these cell fate changes happen is a subject of research interest. ...
Cell & Microbiology
Oct 3, 2018
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The average human has about 37.2 trillion cells. But cells are differentiated for thousands of different functions. How does a cell 'know' which function to fulfill? In a paper published today in Developmental Cell, the group ...
Cell & Microbiology
Oct 12, 2017
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Stem cells ensure the development of tissues, their daily maintenance and their repair following injuries. One of the key questions in the field of stem cell biology is to define the different cell lineages in which stem ...
Cell & Microbiology
Jun 9, 2016
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50
A Johns Hopkins University biologist has led a research team reporting progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.
Cell & Microbiology
Oct 7, 2015
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19
Some 50 years have passed since scientists first proposed the so-called 'inside–outside model' of development, which holds that the inner cells of the early embryo eventually form all the definitive structures of the fetus, ...
Cell & Microbiology
Apr 10, 2013
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Researchers at the A*STAR Institute of Medical Biology (IMB) have discovered a critical checkpoint protein that controls when human embryonic stem cells (hESCs) begin to differentiate.
Cell & Microbiology
Feb 27, 2013
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Every gene in the nucleus of an animal or plant cell is packaged into a beads-on-a-string like structure called nucleosomes: the DNA of the gene forms the string and a complex of proteins called histones forms the beads around ...
Biotechnology
Feb 11, 2013
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Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well ...
Biochemistry
Nov 29, 2012
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