CRISPR-based gene editing has potential therapeutic benefits but also some technical shortcomings. One set of these gene editing tools, base editors, can rewrite the four individual DNA letters, or bases— A, C, T or G—which ...
Biotechnology
Feb 11, 2020
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26
A research team led by Profs. Gao Caixia and LI Jiayang from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have engineered five saturated targeted endogenous mutagenesis editors (STEMEs) ...
Plants & Animals
Jan 13, 2020
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112
In a study published in Nature on June 10, researchers from Dr. Yang Hui's Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational ...
Biotechnology
Jun 10, 2019
2
147
A team of researchers with the Broad Institute of Harvard and MIT has found evidence showing that using base editors can lead to unexpected RNA cellular edits. In their paper published in the journal Science Advances, the ...
Researchers at the Center for Genome Engineering, within the Institute for Basic Science (IBS, South Korea) have identified the mistake rate of DNA editing tools known as adenine base editors, which are based on CRISPR. Assessing ...
Biotechnology
Mar 5, 2019
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17
Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations.
Biotechnology
Feb 28, 2019
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101
Genome editing is used to modify the genes of living organisms to elicit certain traits, such as climate-resilient crops or treating human disease at the genetic level. It has become increasingly popular in agriculture, medicine ...
Education
May 4, 2023
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0
A team of researchers from the Wang Yangming Laboratory at Peking University's College of Future Technology has recently identified a DddA homolog from Simiaoa sunii (Ddd_Ss) that can efficiently deaminate cytosine in DC ...
Biotechnology
Feb 20, 2023
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5
Base editors, which enable production of highly efficient targeted point mutations in genomic DNA without causing double-stranded DNA breaks, hold great promise for gene therapy in human disease and trait improvement in crop ...
Biotechnology
Jul 27, 2020
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5
CRISPR has sparked a renaissance in genome editing. Now, next-generation CRISPR technologies let scientists modify the genome more efficiently and precisely than before. Such tools could one day serve as therapeutics, but ...
Biotechnology
Jun 15, 2020
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