Fluconazole makes fungi sexually active

The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients.

How Candida albicans exploits lack of oxygen to cause disease

Scientists from Umeå university have shown that the yeast Candida albicans can modulate and adapt to low oxygen levels in different body niches to cause infection and to harm the host. Studying adaption to hypoxic or anoxic ...

The mechanisms of genetic diversification in Candida albicans

Candida albicans is one of the most formidable fungal species infecting humans. Investigating the structure and reproduction methods of pathogenic populations can reveal how they emerge and spread. A team of scientists has ...

Fungi found in the guts of healthy adults just travel through

Fungi found in the gastrointestinal tracts of healthy adults are largely transient and stem from the mouth or foods recently consumed, according to new research published this week in mSphere, an open access journal from ...

Driving drug resistance out of fungi

Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch ...

Clues to the innate drug resistance of a cocoa-fermenting pathogen

At first glance, the yeast Candida krusei seems as innocuous as microbes come: it's used for fermenting cocoa beans and gives chocolate its pleasant aroma. But it's increasingly found as a pathogen in immunocompromised patients—and ...

Treating fungal cornea infection with synthetic molecules

A*STAR researchers have created synthetic molecules to treat fungal keratitis – an infection of the cornea that causes visual disability. The new molecules are a first step toward developing effective drugs to combat this ...

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