Search results for CRISPR-Cas9

Bio & Medicine Apr 21, 2022

Nanocapsule carrying a CRISPR-Cas9 editing tool used for noninvasive brain delivery and tumor cell targeting

An international team of researchers has developed a nanocapsule that is capable of crossing the blood brain barrier (BBB) to carry the CRISPR-Cas9 editing tool to treat a brain tumor. In their paper published in the journal ...

Plants & Animals Mar 31, 2022

Piecing thylacine DNA back together

The DNA of extinct species is providing a window into their biology, evolution, and natural history. However, after an animal's death, its DNA invariably breaks into tiny pieces, making it difficult to computationally reconstruct.

Molecular & Computational biology Mar 28, 2022

Progress in developing a hypoallergenic cat

Researchers at InBio (formerly Indoor Biotechnologies), a biotech company in Virginia, report progress en route to developing a hypoallergenic cat—or at least treating patients with allergies to the domestic cat—in a ...

Cell & Microbiology Mar 22, 2022

New CRISPR element regulates viral defense

What tasks need to be done today, and which is the most urgent? People have to constantly set priorities in their daily life. Bacteria are no different: They too must prioritize when combating viruses with CRISPR. However, ...

Biotechnology Mar 16, 2022

New Cas9 model maps DNA cutting behavior for the first time

Researchers from the TU Delft have come up with a physical-based model that establishes a quantitative framework on how gene-editing with CRISPR-Cas9 works, and allows them to predict where, with what probability, and why ...

Molecular & Computational biology Mar 14, 2022

A potential therapy for muscular dystrophy: Using mRNA delivery to improve muscle strength

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, ...

Molecular & Computational biology Mar 11, 2022

Malaria parasite's survival linked to two proteins

Malaria, a mosquito-borne disease, killed more than 620,000 people worldwide in 2020. Jeopardizing the survival of Plasmodium falciparum, the malaria parasite, is one way to control the spread of this deadly disease.

Biotechnology Mar 2, 2022

Gene editing gets safer thanks to redesigned Cas9 protein

One of the grand challenges with using CRISPR-based gene editing on humans is that the molecular machinery sometimes makes changes to the wrong section of a host's genome, creating the possibility that an attempt to repair ...

Molecular & Computational biology Mar 1, 2022

AI-designed protein awakens silenced genes, one by one

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them. Researchers from the University ...

Molecular & Computational biology Feb 28, 2022

Scientists discover new DNA modification system in animals, captured from bacteria more than 60 MYA

Your DNA holds the blueprint to build your body, but it's a living document: Adjustments to the design can be made by epigenetic marks.

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