Search results for CRISPR-Cas9

Cell & Microbiology Apr 22, 2024

A small factor makes a big impact on genome editing

Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to "genome surgery." These tools, including ones based on a natural ...

Cell & Microbiology Apr 19, 2024

Light show in living cells: New method allows simultaneous fluorescent labeling of many proteins

Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge—especially in living cells, as the required fluorescent labeling had to be individually ...

Molecular & Computational biology Apr 4, 2024

Researchers reveal assembly of critical molecular machine that removes non-coding information from genes

One of the most striking features of human genes is that genetic information required to produce proteins is stored in a discontinuous form, wherein the coding information (exons) is punctuated with non-coding segments known ...

Cell & Microbiology Mar 29, 2024

Gene editing technology reveals molecular mechanisms governing diatom population density signals

The intricate dynamics of diatom blooms, influenced by a myriad of external factors and internal signals, continue to fascinate scientists. After recognizing the potential role of density perception and intracellular signaling ...

Cell & Microbiology Mar 29, 2024

Novel role for metabolites in cellular metabolism discovered

Investigators led by Issam Ben-Sahra, Ph.D., associate professor of Biochemistry and Molecular Genetics, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used ...

Cell & Microbiology Mar 28, 2024

Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment

Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. ...

Biotechnology Mar 22, 2024

Messenger RNAs with multiple 'tails' could lead to more effective therapeutics, say researchers

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, ...

Plants & Animals Mar 21, 2024

'Courtship' gene shows different effects in two fruit fly species

A gene associated with courtship behavior in fruit flies does not operate the same way in two different fruit fly species, a new study finds. The work demonstrates that conserved genes—the same genes found across species—do ...

Cell & Microbiology Mar 14, 2024

Researchers reveal dual-function mechanism of bacteriophage-derived protein AcrIIA15

In response to the efficient attacks of the host CRISPR-Cas system, bacteriophages have evolved various resistance strategies, including encoding anti-CRISPR (Acr) proteins. Since their initial discovery in 2013, over a hundred ...

Biotechnology Mar 14, 2024

It's hearty, it's meaty, it's mold: Hacking the genome of fungi for smart foods of the future

With animal-free dairy products and convincing vegetarian meat substitutes already on the market, it's easy to see how biotechnology can change the food industry. Advances in genetic engineering are allowing us to harness ...

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