Search results for author:(John Hewitt)

Cell & Microbiology Feb 3, 2021

Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus

In a recent paper in RNA Biology, researchers show that mitochondria translocate their key RNA methyltransferase enzyme, TRMT1, into host cell nuclei in response to neural activity. This subcellular relocalization of key ...

Evolution Jan 27, 2021

How chromosomes evolve to create new forms of life

3-D printing is a universal process in the sense that pretty much any part that can be drawn up in a CAD program can be printed, at least within a certain resolution. Machining a part on a mill or lathe, while having the ...

Biotechnology Jan 26, 2021

3-D creature construction: Building chromosomes from the ground up

The Genome in a Box project is the brainchild of researchers Anthony Birnie and Cees Dekker from the Dept. of Bionanoscience at the Delft University of Technology. Their stated goal is to assemble a functioning chromosome ...

Cell & Microbiology Jan 15, 2021

Intimate associations between SARS-CoV-2 and mitochondria suggest new angles of attack

As one wise pundit recently observed, "everybody is a virologist now." For the many people whose interest in biology formerly began and ended with "the mitochondria is the powerhouse of the cell," a second axiom can now be ...

Biotechnology Jan 6, 2021

In situ sequencing of the fully structured genome

There is a sense in which the information encoded in a gene sequence can be represented by two bits per base pair location. The reality, however, is that this is far from a complete description. Although many academically ...

Biotechnology Jan 5, 2021

Full mitochondrial control for the ultimate anticancer biohack

Insofar as variants for mitochondrial disease are supposed to be rare in the genome, don't think for even a minute that it can't happen to you. In fact, the closer one looks at the full mitonuclear genomes of normal folks, ...

Molecular & Computational biology Jan 4, 2021

Stopping SARS-CoV-2 in its tracks by blocking its main protease

Inasmuch as therapeutic options against coronavirus have been focused mainly on blocking the interaction between its spike protein and the ACE2 receptor on host cells, SARS-CoV-2 has several additional critical proteins that ...

Biotechnology Dec 24, 2020

Could COVID-19 have wiped out the Neandertals?

Everybody loves Neandertals, those big-brained brutes we supposedly outcompeted and ultimately replaced using our sharp tongues and quick, delicate minds. But did we really, though? Is it mathematically possible that we could ...

Biotechnology Dec 9, 2020

Big data kinase ohmics takes over drug discovery

In order for tumors to successfully take hold and spread in the body, they typically must meet several developmental milestones. These include things like suppressing apoptosis, cultivating replication and angiogenesis, weaning ...

Biotechnology Dec 7, 2020

Introducing MitoCarta 3.0, the definitive guide to the elusive mitochondrial proteome

One of the most hotly contested issues in biology, or at least in mitochondrial biology, is determining which proteins can get into mitochondria. Having this kind of access essentially means a protein maintains a residence ...

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