Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs. In collaboration with scientists ...
Biochemistry
Apr 27, 2023
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54
Scientists from the Florida campus of The Scripps Research Institute have identified a compound that can help repair a specific type of defect in RNA, a type of genetic material. The methods in the new study could accelerate ...
Biochemistry
Jan 18, 2012
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A Scripps Research team has unraveled a new biochemical pathway that triggers a critical repair response to correct errors in the DNA replication process that could otherwise lead to harmful or fatal mutations in cells. Though ...
Aug 6, 2008
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Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute (TSRI) have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials ...
Materials Science
Aug 14, 2014
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For years, science has generally considered the phosphorylation of proteins -- the insertion of a phosphorous group into a protein that turns it on or off -- as perhaps the factor regulating a range of cellular processes ...
Biochemistry
Dec 11, 2011
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Existing flu vaccines provide only limited, seasonal protection because they target highly changeable proteins on the virus. Scripps Research scientists have now designed a vaccine that should work broadly against influenza ...
Bio & Medicine
Dec 8, 2023
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51
Scientists at Scripps Research have identified a group of small molecules that prevent structural changes to proteins that are at the root of AL amyloidosis, a progressive and often fatal disease.
Biochemistry
Apr 12, 2019
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77
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects.
Cell & Microbiology
Mar 31, 2015
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40
An enzyme-blocking molecule can extend the lifespan of Caenorhabditis elegans roundworms by as much as 45 percent, largely by modulating a cannabinoid biological pathway, according to a study from scientists at Scripps Research.
Biochemistry
Mar 26, 2019
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153
After more than a decade of research, Scripps Research Institute scientists have pieced together the structure of a human adenovirus—the largest complex ever determined at atomic resolution. The new findings about the virus, ...
Biochemistry
Aug 26, 2010
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