Bioengineered replacements for tendons, ligaments, the meniscus of the knee, and other tissues require re-creation of the exquisite architecture of these tissues in three dimensions. These fibrous, collagen-based tissues ...
Polymers
Aug 7, 2012
0
0
(PhysOrg.com) -- Taking a cue from the world of business-performance experts and baseball talent scouts, Penn Medicine translational medicine researchers are among the first to find a way to measure the productivity of collaborations ...
Other
Oct 18, 2010
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0
Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles ...
Biotechnology
Mar 21, 2024
0
148
(Phys.org)—Several fatal brain disorders, including Parkinson's disease, are connected by the misfolding of specific proteins into disordered clumps and stable, insoluble fibrils called amyloid. Amyloid fibrils are hard ...
Biochemistry
Nov 19, 2012
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0
The COVID-19 pandemic highlighted the devastating impact of acute lung inflammation (ALI), which is part of the acute respiratory distress syndrome (ARDS) that is the dominant cause of death in COVID-19. A potential new route ...
Bio & Medicine
Dec 27, 2021
1
628
A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making – provides important clues about how the role of timing may influence the way drugs work ...
Biotechnology
Oct 27, 2014
0
0
Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study in Molecular Cell last week by investigators ...
Cell & Microbiology
Jan 5, 2018
2
208
Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple ...
Cell & Microbiology
Sep 26, 2013
0
0
Double-strand breaks in DNA happen every time a cell divides and replicates. Depending on the type of cell, that can be pretty often. Many proteins are involved in everyday DNA repair, but if they are mutated, the repair ...
Cell & Microbiology
Feb 3, 2013
0
0
Researchers from the Perelman School of Medicine and School of Engineering at the University of Pennsylvania and The Children's Hospital of Philadelphia have used graphene—a two-dimensional form of carbon only one atom ...
Nanomaterials
Oct 20, 2014
0
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