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Researchers identify protein with DYRK1A-inhibiting effect that may have implications for Down syndrome

Moderation surpasses excess
DYRK1A bound to FAM53C in the cytoplasm is less active. DYRK1A not bound to FAM53C in the nucleus is highly active. Functional abnormalities cause various neuropsychiatric developmental and functional disorders. Credit: KyotoU/Jake G Tobiyama/Yoshihiko Miyata

Down syndrome, a congenital disorder stemming from abnormal cell division and differentiation, is most common in newborns fated to neurodevelopmental delays and other health complications.

The causes the dysfunction of the protein kinase DYRK1A, which is encoded on chromosome 21 and is deeply associated with both Down syndrome and autism spectrum disorder. DYRK1A has attracted attention as a target molecule for treating various diseases, but specific cellular mechanisms regulating the enzyme DYRK1A have yet to be made clear.

Now, researchers at Kyoto University have identified the FAM53C protein and its DYRK1A-inhibiting effect that keeps the protein kinase inactive inside the cytoplasm.

"Our findings demonstrate the important role of the intracellular regulatory mechanism of DYRK1A in the and function of the neuropsychiatric system," says first author Yoshihiko Miyata at KyotoU's Graduate School of Biostudies.

"The molecular regulation of the highly complex development and activity of the human brain fascinates me," adds Miyata. In addition to neuropsychiatric symptoms, Down syndrome may also cause early onset of Alzheimer's disease, type 2 diabetes, and facial maldevelopment.

"Given DYRK1A's significance, we have explored potential molecules serving as its interacting counterpart," says Miyata.

DYRK1A controls many , including the development and function of the nervous system. At the , this critical protein phosphorylates various other proteins in the cytoplasm and nucleus to regulate the , cell differentiation, cytoskeletal formation, and DNA damage response.

After identifying DCAF7/WDR68 as a major binding protein for DYRK1A in a previous study, Miyata's team used to uncover other interacting proteins that modulate DYRK1A's function and cellular location.

Notably, the structurally flexible FAM53C protein binds directly to a region of DYRK1A responsible for protein phosphorylation. This interaction reduces DYRK1A's kinase activity, securely anchoring DYRK1A within the cytoplasm but outside the cell nucleus, as in normal brain tissue.

"The FAM53C-mediated regulation of the protein kinase activity may significantly impact gene expression regulation caused by normal and aberrant levels of DYRK1A, giving us many potential clinical insights," suggests Miyata.

The work is published in the journal Life Science Alliance.

More information: Yoshihiko Miyata et al, Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A, Life Science Alliance (2023). DOI: 10.26508/lsa.202302129

Provided by Kyoto University

Citation: Researchers identify protein with DYRK1A-inhibiting effect that may have implications for Down syndrome (2023, December 19) retrieved 17 April 2024 from https://phys.org/news/2023-12-protein-dyrk1a-inhibiting-effect-implications-syndrome.html
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