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Researchers develop biodegradable polymers that are traceable without toxic contrast agents

New biodegradable polymers traceable without toxic contrast agents
Real-time 31P{H} NMR spectroscopy gives access to reactivity ratios during copolymerization. PhPPn 1 and MePPn 2 were copolymerized in DCM (4 M) at −10 °C. Shown is an overlay of 31P NMR spectra with highlighted resonances of the monomers before and after incorporation into the copolymer (the interval between the first 10 spectra was set to 5.7 min, for the spectra 10–20 to 11.3 min). Credit: Communications Chemistry (2023). DOI: 10.1038/s42004-023-00954-x

Polyphosphoesters, molecules containing phosphorus as the central element, are easily traceable without the need for contrast agents, thanks to developments by researchers from the University of Twente (UT). Normally, these molecules display a similar molecular composition to our DNA, leading to considerable "noise" in the image.

The UT researchers provided a solution and developed unique polymers that are traceable with magnetic resonance imaging (MRI). Dr. Olga Koshkina, Project Leader in the Sustainable Polymer Chemistry Group, published this new concept of traceable polymers in Communications Chemistry.

The researchers adjusted the properties of polyphosphoesters (special polymers with a molecular structure inspired by DNA and RNA). As a result, the polymers acquired a different "MRI color," making them more distinguishable from the natural background. Additionally, they exhibit other physical MRI characteristics suitable for imaging.

For certain , polymers need to be traced within the body, a task typically accomplished through MRI. However, to effectively image by MRI, toxic contrast agents are often required

MRI and MRI contrast agents

MRI is a radiation-free imaging technique routinely used in clinics today. Medical examinations using MRI typically require contrast agents. Current clinical often alter the contrast of body water and tissues by employing paramagnetic heavy metals such as gadolinium to modify the signal from body water.

While efficient in imaging, the use of heavy metals raises concerns due to their accumulation in the body and the environment. Heteronuclear "hotspot" MRI does not require metals and directly detects other MRI-active elements. These elements serve as MRI dyes, creating a new color on an anatomical image.

Polymers in biomedical applications

Polymeric materials have enormous potential in , including the development of new therapies. However, to develop effective personalized treatments, it is crucial to track polymers in vivo. Until now, this was only possible with additional labeling, such as attaching for or fluorine-containing molecules (also called "PFAS") for "hotspot" MRI.

UT introduces a new concept, in which polymers can be tracked without a label, using directly the phosphorus signal in the polymer's molecular structure.

New possibilities

The research opens a new avenue for traceable and sustainable polymers with MRI. They can be used as new MRI agents, as drug delivery vehicles, or as biomaterials for tissue regeneration. The researchers at the University of Twente plan to conduct further in this area and have opened up new possibilities for biodegradable, traceable polymers.

In addition, they are currently working on establishing a spin-off company to ensure that this groundbreaking research can be applied to real patients in the long term.

More information: Timo Rheinberger et al, Real-time 31P NMR reveals different gradient strengths in polyphosphoester copolymers as potential MRI-traceable nanomaterials, Communications Chemistry (2023). DOI: 10.1038/s42004-023-00954-x

Journal information: Communications Chemistry

Citation: Researchers develop biodegradable polymers that are traceable without toxic contrast agents (2023, November 24) retrieved 29 February 2024 from
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