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New process simulates rapid decomposition of drugs to facilitate stability testing

For shorter approval times: New process simulates decomposition of too long stored drugs in 15 minutes
Jars with compounds in the laboratory (Symbolic picture) Credit: LIKAT/Nordlicht

Before their approval, pharmaceuticals not only have to be tested for their effectiveness and safety, but also for their stability, since they are usually stored in pharmacies and private households for years. To test stability, a process is needed that decomposes a drug "in fast motion."

Such a method was recently developed by a team of scientists from the Leibniz Institute for Catalysis in Rostock (LIKAT), the RWTH Aachen University and the Julius Maximilian University of Würzburg, accompanied by the company RD&C (Vienna, Austria). The research results have now been published in the journal ACS Central Science.

Virtually all drugs are multicomponent or multiphase systems that are embedded in a matrix, i.e., contain excipients and carriers, for example. These additives can interact with the active ingredient over time, for example when the drugs are stored for a longer period of time and impair the effect of the drug. The must disclose all stability data before a new drug is approved, so there is considerable interest in developing reliable predictive tools to assess the safety of drugs.

Currently, however, such predictive tools for solid-state properties, particularly with respect to solid-state stability and degradation, are limited. In addition, the rate and decomposition products of solid-state degradation processes are unique for each compound, making the development of stability models very time-consuming and costly. Prediction methods in aqueous environments exist, but they lead to high error rates. Since irrelevant degradation products are often formed under these conditions, these imply a high financial and health development risk for the manufacturer of new drugs and for the customer.

Based on proof-of-concept studies successfully performed by RD&C and the team, a unique and innovative experimental method for predicting stability profiles and degradation pathways in solid compounds, mixtures and matrices has now been developed. In the literature, the approach is referred to as "mechanochemistry." In this approach, the isolated drug or marketed pharmaceutical product is treated in a vibrating mill in the presence of a decomposition-inducing reagent. Within less than 15 minutes, degradation processes can be observed.

Everaldo Krake (LIKAT Rostock), first author of the study and a newly graduated scientist, explains, "We were able to show this on a series of structurally similar so-called thienopyridines, which are the drugs in antiplatelet tablets. Crucial to the success was the collaboration with the group led by Carsten Bolm (RWTH Aachen University), a world-leading expert in the field of mechanochemistry, and the team of Ulrike Holzgrabe (University of Würzburg), a renowned pharmaceutical chemist. This showed that the degradation profiles are identical for both the pure drug and the finished pharmaceutical product. This means that reproducible and relevant statements can be made for this class of drugs in short reaction times using the alone. This would be of great importance for accelerated drug approval."

According to the authors, this new approach represents a in the application of mechanochemical processes in . "In general, mechanochemical studies of the transformation of small organic molecules, particularly drugs, are carried out with the aim of producing specific structural motifs. The new work now published highlights the potential of this approach to also target specific structural motifs for degradation," says Carsten Bolm.

This could be important not only for , but also for organic synthesis in general. "In the future, it will be interesting to apply this mechanochemical approach to other drug families and to evaluate the role of other stimuli such as light or temperature for the forced degradation process," Ulrike Holzgrabe concludes.

More information: Everaldo F. Krake et al, Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability, ACS Central Science (2023). DOI: 10.1021/acscentsci.3c00167

Journal information: ACS Central Science

Provided by Leibniz-Institut für Katalyse

Citation: New process simulates rapid decomposition of drugs to facilitate stability testing (2023, May 25) retrieved 18 April 2024 from
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