Breakthrough in protecting bananas from Panama disease

Breakthrough in protecting bananas from Panama disease
Fungicides and protection of bananas against Panama disease. A Whole-plant symptoms of Panama disease at 56 days after root inoculation with chlamydospores, followed by 2 applications of fungicides or the solvents 0.14% (v v-1) DMSO or 0.16% (v v-1) methanol in water (Control (+)). The negative control (Control (-)) was only treated with the solvent. B Corm necrosis in bananas at 56 days after root inoculation with chlamydospores, followed by 2 treatments with fungicides. Control (+) indicates inoculation with spores, followed by treatment with 0.16% (v v-1) methanol (positive control). Scale bar = 2 cm. C Quantitative assessment of darkening of corm tissue after inoculation with chlamydospores followed by 2 treatments with fungicides. Banana corm necrosis was analyzed 56 days after the first treatment. Light blue: Controls; dark blue: fungicide treatments. Bars in (C) show mean ± SEM from 18–24 measurements of 9–12 plants from 3–4 experiments; statistical comparison in (C) used Student’s t-testing with Welch correction; n.s. = non-significant difference to respective control at two-tailed error probability of P = 0.7074 (Mancozeb) and P = 0.1871 (Copper); * = significant difference to control at two-tailed at P = 0.0452 (Chitosan); ** = significant difference to control at two-tailed at P = 0.006 (Captan); **** = significant difference to control at two-tailed P<0.0001. Plant infection assays used LMW chitosan, 200 μg ml-1 (applied as 333 μg ml-1 lactate salt); copper, 200 μg ml-1 (applied as 786 μg ml-1 copper (II) sulfate pentahydrate); mancozeb, 70 μg ml-1; captan, 20 μg ml-1; CTAB, 200 μg ml-1; dodine, 200 μg ml-1; C18DMS, 200 μg ml-1. Credit: PLOS Pathogens (2022). DOI: 10.1371/journal.ppat.1010860

Exeter scientists have provided hope in the fight to control Panama disease in bananas.

Bananas are amongst the most popular fruits eaten world-wide. They are grown and eaten locally, providing food for almost half a billion people, and banana exports generate precious income.

In the 1950s, Panama disease, caused by the fungus Fusarium oxysporum cubense Race 1, decimated the world's banana supply. This disaster was overcome by the introduction of a new Cavendish variety . However, a new race of the fungus, known as Tropical Race 4, recently swept across the continents and through the Cavendish banana plantations. This new Panama disease threat is of particular significance as Cavendish bananas account for about 40% of world production and more than 90% of all exports. All efforts to control the disease in Cavendish bananas have, so far, failed.

In this new study, reported in the journal PLOS Pathogens, University of Exeter scientists provide hope that Panama disease can be controlled by a particular class of anti-fungal chemistries (fungicides).

An Exeter team led by Professor Steinberg and Professor Sarah Gurr used a multi-disciplinary approach, to better understand why chemical control of Panama disease had failed. By combining expertise in cell and , bioinformatics and plant pathology, the team revealed that all major classes of fungicides do not work against this troublesome pathogen and provide insight for the molecular reason behind this "resistance."

Guided by this understanding, the research team discovered that a more specialized class of anti-fungal chemistries, not previously used, suppress Panama disease and maintain banana plant health in the presence of the pathogen. This discovery opens new avenues to develop efficient control strategies and provides a significant step forwards in the fight to protect this valuable crop.

Professor Steinberg, who led the molecular and cellular aspects of the work, said, "Bananas are Britain's favorite fruit and Panama disease may 'wipe' them off the supermarket shelves. On top, millions of people in producer countries live on bananas. Providing an important step towards safeguarding bananas from Panama disease gives me great pride."

Professor Sarah Gurr, the plant pathology expert who led all work on banana infection and pathogen cultivation, said, "Our success is due to an enormous amount of dedicated work over several years with co-workers with hugely disparate skills. We are highly delighted and excited by the outcome of our work and by the glimmer of hope that the beloved banana may remain as part of our daily diet."

Professor Dan Bebber, who was not involved in the study but heads the Exeter Global Food Security program, said, "This work has rather excitingly opened the door to development of safe and effective ways of protecting the U.K.'s favorite fruit by demonstrating good levels of disease control with lesser known antifungals. It also confirms that basic research has the potential to provide answers to pressing challenges in global food security."

The University of Exeter realizes the potential social impact of this study. Dr. Tori Hammond, from Innovation, Impact and Business at the University of Exeter, said, "Prof Steinberg and Prof Gurr's work has resulted in an exciting and innovative technology breaking out of the lab and towards commercialization. The potential impact of this technology on the global bioeconomy is incredibly significant."

The paper, published in the journal PLOS Pathogens, is entitled, "Multi-site fungicides suppress banana Panama , caused by Fusarium oxysporum f. sp. cubense Tropical Race 4."

More information: Stuart Cannon et al, Multi-site fungicides suppress banana Panama disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4, PLOS Pathogens (2022). DOI: 10.1371/journal.ppat.1010860

Journal information: PLoS Pathogens

Citation: Breakthrough in protecting bananas from Panama disease (2022, October 21) retrieved 18 May 2024 from
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