Waste coffee grounds could someday help detect brain waves

coffee grounds
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There's nothing like a steaming cup of joe to give your morning a quick boost. Now, there's yet another reason to love the beverage. Today, researchers report the first application of used coffee grounds as environmentally friendly electrode coatings for sensitive neurochemistry measurements. The material could eventually help scientists get a better handle on brain activity and detect minute levels of neurotransmitters.

The researchers will present their results at the spring meeting of the American Chemical Society (ACS).

Spent have previously been used to make supercapacitors for energy storage. But now, new research led by principal investigator Ashley Ross, Ph.D., has taken recycled waste in another, more biological direction. She and her team have demonstrated that electrodes coated with from this waste can detect trace levels of biomolecules in vitro. According to Ross, this is the first example of residual coffee grounds being repurposed for biosensing applications.

"I saw papers about using spent grounds to produce porous carbon for , and I thought maybe we could use this conductive material in our neurochemistry detection work," says Ross. "And I also thought this would be a good excuse to buy lots of coffee for the lab!" Ross, who is at the University of Cincinnati, and several members of her team are self-professed coffee lovers.

The traditional microelectrodes that neuroscientists use are commonly made from —fine, solid carbon strands bundled together. Making them is typically an arduous and expensive process, involving multiple steps and harsh chemicals. Eventually, Ross wants to fabricate entire electrodes with carbon from coffee grounds because this type of approach would be inexpensive and environmentally friendly. As a first step toward realizing that goal, the researchers adapted the material from the grounds as a coating for conventional electrodes.

Kamya Lapsley, who was a summer student in Ross's lab and who is currently an at Kent State University, took this initial challenge on. She and other members of the lab dried used coffee grounds and heated them in a tube furnace at about 1,300 F. Next, they added the material to a potassium hydroxide solution to activate the carbon and open up holes in the structure. Then, the researchers heated the mixture again under nitrogen gas to remove any undesired byproducts. What was left was an inky slurry full of flecks of porous carbon. As a final step, the researchers diluted the sludge with water, into which they dipped the carbon fiber electrodes to coat them with a layer of porous carbon nearly a hundred times thinner than the diameter of a human hair.

The researchers compared the performance of coated and uncoated electrodes for sensing small quantities of dopamine, a neurotransmitter, with fast-scan cyclic voltammetry. With this technique, they applied a rapidly varying voltage to the electrode to alternately oxidize and reduce dopamine. The technique is fast enough to detect subsecond neurotransmitter release, as would happen in the brain. The researchers found that electrodes coated with porous carbon reached oxidative current levels over three times higher than bare carbon fibers in the presence of dopamine, indicating that the coated electrode offered a more sensitive surface for dopamine detection. Not only does the porous structure allow more dopamine molecules to participate in the reaction because of the coating's large surface area, it also momentarily traps dopamine molecules in the crevices of the electrode, says Ross. These properties increase the sensitivity and allow the researchers to carry out faster measurements. The group is now exploring how these porous coatings impact the temporal resolution of the technique.

Next, the team will make carbon fiber electrodes from scratch with porous carbon from waste coffee grounds, which would give the electrodes uniform porosity not just on the surface, but also through and through. Ross predicts that this will boost their neurochemical detection abilities because an even larger total surface area of the will be exposed to adsorb the dopamine molecules. At the same time, Ross plans to put the current coffee-coated electrodes to the test in the brains of live rats.

In the meantime, there will be no lack of starting materials to carry out the next stages of the project, for the entire lab seems to love their brew. "The grad students provided quite a bit of coffee grounds—more than we will ever need," says Ross. "My entire lab really loved this project."


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More information: Deriving porous carbon from waste coffee grounds for sensitive dopamine detection with fast-scan cyclic voltammetry, ACS Spring 2022. acs.digitellinc.com/acs/live/22/page/677
Citation: Waste coffee grounds could someday help detect brain waves (2022, March 20) retrieved 28 June 2022 from https://phys.org/news/2022-03-coffee-grounds-brain.html
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