500 years later, scientists finger germ behind Mexican 'pestilence'

January 15, 2018
Overview of Teposcolula-Yucundaa, showing its location in the Mixteca Alta region of Oaxaca, Mexico (A), and its central administrative area (B), where excavations took place. (C) shows a drawing of individual 35, from which an S. enterica genome was isolated. Credit: Åshild J. Vågene et al. Salmonella enterica genomes from victims of a major 16th century epidemic in Mexico. Nature Ecology and Evolution.

In 1545, disaster struck Mexico's Aztec nation when people started coming down with high fevers and headaches, bleeding from the eyes, mouth and nose. Death generally followed in three or four days.

Within five years, as many as 15 million people—an estimated 80 percent of the population—were wiped out in an epidemic the locals named "cocoliztli".

The word means "pestilence" in the Aztec Nahuatl language. Its cause, however, has been in question for nearly 500 years.

On Monday, scientists swept aside smallpox, measles, mumps, and influenza as likely suspects, fingering a typhoid-like "enteric fever" for which they found DNA evidence on the teeth of long-dead victims.

"The 1545-50 cocoliztli was one of many epidemics to affect Mexico after the arrival of Europeans, but was specifically the second of three epidemics that were most devastating and led to the largest number of human losses," said Ashild Vagene of the University of Tuebingen in Germany.

"The cause of this epidemic has been debated for over a century by historians and now we are able to provide direct evidence through the use of ancient DNA to contribute to a longstanding historical question," she told AFP.

Vagene co-authored a study published in the science journal Nature Ecology & Evolution.

The cocoliztli outbreak is considered one of the deadliest epidemics in human history, approaching the "Black Death" bubonic plague that felled some 25 million people in western Europe in the 14th century—about half the regional population.

Excavated structure at the northern edge of the Grand Plaza at Teposcolula-Yucundaa. Architectural investigations of the Grand Plaza resulted in the unexpected discovery of a large epidemic cemetery associated with the 1545-1550 cocoliztli epidemic. The cemetery was found to contain numerous mass burials, attesting to the catastrophic nature of the epidemic. Credit: Christina Warinner. The Teposcolula-Yucundaa Archaeological Project.

European colonisers spread disease as they ventured into the New World, bringing germs that local populations had never encountered, and therefore had no immunity against.

The 1545 cocoliztli pestilence in what is today Mexico and part of Guatemala came just two decades after a smallpox epidemic killed an estimated 5-8 million people in the immediate wake of the Spanish arrival.

'Strong candidate'

A second cocoliztli outbreak from 1576 to 1578 killed half the remaining population.

"In the cities and large towns, big ditches were dug, and from morning to sunset the priests did nothing else but carry the dead bodies and throw them into the ditches," is how Franciscan historian Fray Juan de Torquemada is cited as chronicling the period.

Even at the time, physicians said the symptoms did not match those of better-known diseases such as measles and malaria.

On Monday, scientists said they have likely unmasked the culprit.

Analysing DNA extracted from 29 skeletons buried in a cocoliztli cemetery, they found traces of the salmonella enterica bacterium, of the Paratyphi C variety.

Åshild J. Vågene conducting lab work at the Max Planck Institute for the Science of Human History. Credit: Elizabeth Nelson

It is known to cause enteric fever, of which typhoid is an example. The Mexican subtype rarely causes human infection today.

Many salmonella strains spread via infected food or water, and may have travelled to Mexico with domesticated animals brought by the Spanish, the research team said.

Salmonella enterica is known to have been present in Europe in the Middle Ages.

"We tested for all bacterial pathogens and DNA viruses for which genomic data is available," and salmonella enterica was the only germ detected, co-author Alexander Herbig, also from Tuebingen University, told AFP.

It is possible, however, that some pathogens were either undetectable, or completely unknown.

"We cannot say with certainty that S. enterica was the cause of the cocoliztli epidemic," said team member Kirsten Bos.

"We do believe that it should be considered a strong candidate."

Explore further: Epidemic outbreaks caused by environment, not evolution

More information: Åshild J. Vågene et al, Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico, Nature Ecology & Evolution (2018). DOI: 10.1038/s41559-017-0446-6

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Thorium Boy
1 / 5 (2) Jan 16, 2018
No proof it came from Europe, only speculation. Given the environment, it's very likely it originated in the local environment, just like ebola and related diseases in Africa.
a_whitefree_europe
5 / 5 (1) Jan 16, 2018
There's no proof it originated in the local environment thorium boy, only speculation.
rrwillsj
1 / 5 (1) Jan 16, 2018
Common on TB... Where's your 'White Pride'? That we 'Euro-eccentrics' managed to inflict horrendous plagues upon the unwary indigenous of the world.

On top of all the rape, plunder and murder that make us the premier example of the Species Homo Anthropophagus!

Golly, man. It is our "Proud Legacy of Our Peculiar Institution'. To be remembered as right bastards for a thousand years.

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