Compounds in an Asian fermented fish paste could reduce high cholesterol

September 12, 2017, Universiti Putra Malaysia (UPM)
Compounds in an Asian fermented fish paste could reduce high cholesterol
Fermenting carp fish leads to the release of compounds that could play a role in reducing cholesterol levels. Credit: W.A. Djatmiko/C-C Wikimedia

Compounds in a fermented fish paste used as a condiment in Indonesia efficiently inhibit an enzyme involved in cholesterol synthesis, reports a study published in the Pertanika journal Tropical Agricultural Science.

Researchers from Sriwijaya University in Indonesia tested the effects of various filtered out of bekasam, a fermented fish paste used in Indonesian cooking, on the enzyme HMG-CoA reductase. They found two peptides inhibited the enzyme.

HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, a necessary step in in the body. Previous studies have reported that some fermented fish products can block this enzyme's activity.

The team prepared bekasam from carp fish that was gutted, washed and soaked in a culture of the bacterium Lactobacillus acidophilus for 30 minutes. The were then removed from the culture, mixed with salt and rice, and fermented for seven days. An extract was derived from the resulting bekasam by mixing it with distilled water, centrifuging it, and then filtering it through a tiny membrane. The filtrates were separated according to their molecular size.

A known as lovastatin, found in high concentrations in the extract, successfully inhibited HMG-CoA reductase in an experiment designed to test the enzyme's activity. Another peptide with a larger molecular weight was also found to inhibit HMG-CoA reductase with high efficiency.

During the fermentation process, bacteria help break down proteins into peptides and amino acids. "The use of Lactobacillus acidophilus as a starter culture in the fermentation of bekasam increases the bioactive compounds of HMG-CoA reductase inhibitors," write the researchers in their study.

The team next plans to develop a cholesterol-lowering supplement from bekasam, says Rinto of Sriwijaya University's fisheries technology program, who co-authored the study.

Explore further: Research proves new soybean meal sources are good fish meal alternatives

More information: Fractionation of Anticholesterol Bioactive Compounds from Bekasam (Indonesian Fermented Fish Product). www.pertanika.upm.edu.my/Perta … 87-2017-5thProof.pdf

Related Stories

Researchers unlock cheesemaking secret

August 17, 2017

Researchers say their new knowledge on the inner workings of a bacterium has important implications for Australia's billion dollar cheese industry.

Recommended for you

After a reset, Сuriosity is operating normally

February 23, 2019

NASA's Curiosity rover is busy making new discoveries on Mars. The rover has been climbing Mount Sharp since 2014 and recently reached a clay region that may offer new clues about the ancient Martian environment's potential ...

Study: With Twitter, race of the messenger matters

February 23, 2019

When NFL player Colin Kaepernick took a knee during the national anthem to protest police brutality and racial injustice, the ensuing debate took traditional and social media by storm. University of Kansas researchers have ...

Solving the jet/cocoon riddle of a gravitational wave event

February 22, 2019

An international research team including astronomers from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has combined radio telescopes from five continents to prove the existence of a narrow stream of material, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.