Molecular architects—how scientists design new materials

Molecular architects—how scientists design new materials
Nano-architects design materials that can work together at very tiny scales, like these interlocking gears made of carbon tubes and benzene molecules. Credit: NASA

When Thomas Edison wanted a filament for his light bulb, he scoured the globe collecting thousands of candidates before settling on bamboo. (It was years before people were able to make tungsten work properly.) That's our traditional way of getting materials. We picked up stones for axes, chopped wood for housing and carved tools out of bone.

Then we learned to synthesize new materials out of old ones, like shaping clay into bricks or pots and baking them into stone. Plastics entered our repertoire as a concoction of cotton, acid and wood tar.

Much of the quest for novel materials has moved into science labs. The search is more efficient than when Albertus Magnus (allegedly) synthesized the Philosopher's Stone, but the game is still intelligent serendipity. We try combinations of ingredients, combinations of heating, mixing and other processes, and hope that one of them works. During the last few decades, a scaled-up, highly organized and automated search system called "combinatorial chemistry" has produced new drugs and materials including automotive coatings, , materials for solar cells, metal alloys and organic dyes.

Architects and engineers do not wait on search or serendipity to produce a novel bridge that doesn't collapse under a 10-ton truck. They use established principles, paper and pencil (and software) to produce a design that they can confirm, by computation and deduction, will meet the necessary specifications. Today's chemists and are taking a similar approach, pushing forward a materials revolution.

Molecular architects—how scientists design new materials
At left, the design of a single tile of a nanogrid made of DNA; at right, the grid as viewed by an atomic force microscope. Credit: Strong, 2004, CC BY

The challenges of design-build planning

One of the great technological challenges of this century is to design to satisfy given specifications – and then, when the material is synthesized, have it meet those specifications. Just as builders can make a house out of bricks and beams and mortar using a blueprint indicating where the bricks and beams go, scientists conceive of synthesizing a material out of molecules using a blueprint indicating where the "" go.

But there is a problem. Unlike bricks, beams and mortar, people cannot pick up atoms or molecules with their hands and place them in a structure. This must be done indirectly, rather like modern construction: just as we have cranes, pulleys and other devices for manipulating beams, panels and prefabricated modules, we need devices for manipulating the atoms or molecules to get them into place – and then welding them together.

Working with DNA

Let's consider one (very nice) example: DNA. With current technology, DNA is much more easily manipulated than other materials; during the past few decades, we have developed many ways to manipulate DNA molecules. In 1980, Nadrian Seeman looked at M.C. Escher's "Depth," an infinite regular array of fish, and decided to make it – which he ultimately did three decades later. In between, he made a cube of DNA; Paul Rothemunde made a DNA smiley face, Leonard Adleman showed how DNA can compute things and a whole community arose making nano-things out of DNA.

Rothemunde's smiley face is a likely harbinger of things to come. It is a sort of nano-textile, with a very long DNA strand, folded back and forth so that it covers a circle. Two hundred short strands – "staples" – hold the long strand together. It isn't just the outline (the long strand with its folds and staples) that is designed in advance. Each DNA strand has its own code, which can be used to control how different DNA strands bond to each other. The codes of the long strand and the staples are computed in advance, and from these designs, strands are synthesized and mixed together to produce the intended structure.

Expanding to more difficult compounds

Meanwhile, chemists and materials scientists are making progress on less controllable materials, like proteins and crystals. For example, a decade ago, Omar Yaghi, Michael O'Keeffe and four colleagues published a manifesto on "reticular synthesis" in nature. They observed that crystals have regular molecular structures, and proposed that chemists should design a structure and then make crystals from the design.

One of the major efforts is making a porous crystal that can serve as a safe and stable storage tank for hydrogen powered cars. (Porous crystals, with nanoscale channels and chambers, are not oddities: you may find some in the catalytic converter in your car or even your cat's litter box.)

Many of our major will require with specific properties, whether for a new drug, a solar panel, a computer chip or airplane skin. When we see progress in medicine, energy, computing power and transportation, the revolution is an integral part of the scientific process of discovery.

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Source: The Conversation

This article was originally published on The Conversation. Read the original article.
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