Image sensor for analysis of blood samples for early diagnosis of diabetes and Alzheimer's disease

September 24, 2014, Toyohashi University of Technology
Image sensor for analysis of blood samples for early diagnosis of diabetes and Alzheimer’s disease
Fig. 1: Semiconductor image sensor

Professor Kazuaki Sawada and Dr. Takigawa of the National Center for Geriatrics and Gerontology and colleagues at Toyohashi University of Technology have established an easy to use, low-cost, rapid, and high sensitivity semiconductor-imaging based medical diagnostic biosensing system for analyzing blood and urine for early diagnosis of ailments including diabetes and Alzheimer's disease.

The new biosensing technology consists of a semiconductor image sensor ( 'charge coupled device' developed by Toyohashi University of Technology) that is sensitive to extremely small changes in electric potential, and microbeads on which antigen-antibody reactions take place. This technology will enable monitoring and diagnosis of diseases for which specific markers are known using very small volumes of blood or urine. Specifically, this technology has detected amiloid beta-peptide, an agent responsible for Alzheimer's disease.

Contracting a disease leads to expression of proteins specific to the diseases in the blood. This new technology is used for early diagnosis of diseases by using this specific protein as the antigen and a marker that captures the protein as the antibody and checking their antigen-antibody reaction. Conventional protocols used to monitor antibody-antigen reactions employ fluorescent probes and detection of fluorescence with microscopic cameras. This process is time consuming because of the necessity to measure fluorescence from the probes and cannot be used to detect low concentrations of antigens when the fluorescence intensity is too low to detect optically.

With this technology, an antigen-antibody reaction is used as in conventional methods, but fluorescence is not measured. Instead, this method employs a semiconductor image sensor to detect minute changes in electric potential generated during an antigen-antibody reaction.

Fig. 2: Schematic illustration of microbeads with antibodies on sensors (Patent application filed)

The semiconductor [Fig. 1] consists of 128 × 128 pixels that independently sense minute changes in . The detection sensitivity of antigen-antibody reactions was significantly increased by using microbeads [Fig. 2]. The figures of merit of this technology are given in Table 1. Multiple diseases can also be simultaneously diagnosed by placing different antibodies on different sensing pixels out of a total of 16,384 pixels (128×128).

Table 1: Advantage of this technology over the conventional method

Implementation of the technology will be tested for daily control of lifestyle diseases such as diabetes and in future the will be expanded for the of Alzheimer's and Parkinson' diseases.

Explore further: New recombinant antibody can isolate stem cells from umbilical cord blood

More information: Akiteru Kono et al, "Label free bio image sensor for real time monitoring of potassium ion released from hippocampal slices," Sensors and Actuators B 201, 439–443, (2014).

Related Stories

New technique could benefit Alzheimer's diagnosis

September 1, 2014

Swinburne researchers have developed a technique to create a highly sensitive surface for measuring the concentration of a peptide that is a biomarker for early stage Alzheimer's disease.

New Device Shines Light on Disease-Causing Molecules

July 8, 2008

If a doctor could identify a single molecule indicating the presence of a disease before the disease has a chance to harm the patient, the practice of medicine and the health of patients would be greatly improved. That’s ...

A blood test for Alzheimer's disease?

January 6, 2011

Scientists from the Florida campus of The Scripps Research Institute, have developed a novel technology that is able to detect the presence of immune molecules specific to Alzheimer's disease in patients' blood samples. While ...

Recommended for you

Coffee-based colloids for direct solar absorption

March 22, 2019

Solar energy is one of the most promising resources to help reduce fossil fuel consumption and mitigate greenhouse gas emissions to power a sustainable future. Devices presently in use to convert solar energy into thermal ...

EPA adviser is promoting harmful ideas, scientists say

March 22, 2019

The Trump administration's reliance on industry-funded environmental specialists is again coming under fire, this time by researchers who say that Louis Anthony "Tony" Cox Jr., who leads a key Environmental Protection Agency ...

The taming of the light screw

March 22, 2019

DESY and MPSD scientists have created high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.