Researchers discover how mole rat wards off cancer

Researchers discover how underground rodent wards off cancer
A blind mole rat is shown on the background of dying necrotic blind mole rat cells. Credit: University of Rochester

Biologists at the University of Rochester have determined how blind mole rats fight off cancer—and the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat.

The team of researchers, led by Professor Vera Gorbunova and Assistant Professor Andrei Seluanov, found that abnormally growing cells in blind mole rats secrete the protein, which causes those cells to rapidly die. Seluanov and Gorbunova hope the discovery will eventually help lead to new cancer therapies in humans. Their findings are being published this week in the .

Blind mole rats and naked mole rats—both subterranean rodents with long life spans—are the only mammals never known to develop cancer. Three years ago, Seluanov and Gorbunova determined the anti-cancer mechanism in the . Their research found that a specific gene—p16—makes the in naked mole rats hypersensitive to , and stops them from proliferating when too many crowd together.

"We expected blind mole rats to have a similar mechanism for stopping the spread of cancerous cells," said Seluanov. "Instead, we discovered they've evolved their own mechanism."

Gorbunova and Seluanov made their discovery by isolating cells from blind mole rats and forcing them to proliferate in culture beyond what occurs in the animal. After dividing approximately 15-20 times, all of the cells in the culture dish died rapidly. The researchers determined that the rapid death occurred because the cells recognized their pre-cancerous state and began secreting a suicidal protein, called interferon beta. The died by a mechanism which kills both and their neighbors, resulting in a "clean sweep."

"Not only were the cancerous cells killed off, but so were the adjacent cells, which may also be prone to tumorous behavior," said Seluanov.

"While people don't use the same cancer-killing mechanism as blind mole rats, we may be able to combat some cancers and prolong life, if we could stimulate the same clean sweep reaction in cancerous human cells," said Gorbunova.

The research team also included Christopher Hine, Xiao Tian, and Julia Ablaeva in Rochester, Andrei Gudkov at Roswell Park Cancer Institute in Buffalo, NY, and Eviatar Nevo at the University of Haifa in Israel.

Gorbunova and Seluanov say they next want to find out exactly what triggers the secretion of interferon beta after cancerous cells begin proliferating in blind mole rats.

Gorbunova believes the anti-cancer mechanism is an adaptation to subterranean life. "Blind mole rats spend their lives in underground burrows protected from predators," said Gorbunova. "Living in this environment, they could perhaps afford to evolve a long lifespan, which includes developing efficient anti-cancer defenses."


Explore further

Scientists discover gene that 'cancer-proofs' rodent's cells

More information: "Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism," by Vera Gorbunova et al. www.pnas.org/content/early/201 … /31/1217211109.short
Citation: Researchers discover how mole rat wards off cancer (2012, November 5) retrieved 21 August 2019 from https://phys.org/news/2012-11-mole-rat-wards-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Nov 05, 2012
If they evolved a method to defeat cancer perhaps its beccause they at one point had to survive in conditions that required them to obtain cancer to succesfully reproduce.

Nov 05, 2012
If they evolved a method to defeat cancer perhaps its beccause they at one point had to survive in conditions that required them to obtain cancer to succesfully reproduce.


That's true in a completely different way than you realize. When the engine your genetic progress is mutation and death, there's going to be a cancer tax.

Nov 06, 2012
There must have been a reason for the adaptation. They might live in conditions that would promote or encourage the development of cancer. Maybe living underground would expose them to more radioactive elements or carcinogens. It would be amazing if they could reproduce this type of adaptation in humans, perhaps through genetic engineering.

Nov 06, 2012
If technology develops the ability to insert these anti-cancer genes into the human genome, the opposition to human germline GM will evaporate. Even if such practices were outlawed, rich parents would pay labs abroad to get children immune from cancer.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more