Overcoming genomic imprinting barrier improves mammal cloning

Somatic cell nuclear transfer (SCNT, also known as cloning) technology holds great potential in animal production and regenerative medicine. However, the extremely low efficiency and frequently observed abnormalities in cloned ...

Lipid metabolism controls brain development

Neural stem cells are not only responsible for early brain development—they remain active for an entire lifetime. They divide and continually generate new nerve cells and enable the brain to constantly adapt to new demands. ...

Hidden messages in protein blueprints

Scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM) and the Max Planck Institute in Freiburg have identified a new control mechanism ...

A molecular atlas of skin cells

Skin is protective against physical injury, radiation and microbes, and at the same time, produces hair and facilitates perspiration. Details of how skin cells manage such disparate tasks have so far remained elusive. Now, ...

Curing genetic disease in human cells

While the genome editing tool CRISPR/Cas9, developed in 2012, cuts a mutation out of a gene and replaces it with a gene-piece, a newer type of CRISPR, called base-editing, can repair a mutation without cutting the DNA. Therefore, ...

Researchers decode the circuitry of neuromuscular organoids

The Gouti lab from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) has developed functional neuromuscular organoids (NMOs) that self-organize into spinal cord neurons and muscle tissue. ...

New method to purify cell types to high purity

Researchers from the group of Alexander van Oudenaarden at the Hubrecht Institute (KNAW) have developed GateID, a new method that can purify a cell type of interest from a tissue without the use of antibodies or a genetic ...

Cause of rare but deadly neurological disease identified

A deadly neurological disease that primarily affects infant boys is caused by increased sensitivity to iron in the brain, according to a new study by researchers at the Stanford University School of Medicine, the University ...

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