Biomolecules, as physical systems, are distinct molecular entities synthesized or utilized by living organisms that exhibit specific structural, thermodynamic, and dynamical properties enabling biological function. They include nucleic acids, proteins, lipids, carbohydrates, and diverse metabolites, each characterized by defined covalent connectivity, three-dimensional conformations, and interaction potentials with solvents, ions, and other biomolecules. Their behavior is governed by quantum-mechanical bonding, classical electrostatics, and statistical thermodynamics, leading to emergent phenomena such as self-assembly, allostery, enzyme catalysis, and molecular recognition. In physical systems research, biomolecules are studied through techniques like spectroscopy, crystallography, cryo-EM, and molecular simulations to elucidate structure–function relationships and energy landscapes.
The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new study in Scientific Reports, Noah Joseph, and a team of biotechnology and nanoscience ...
Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles ...
Bio & Medicine
Oct 30, 2023
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Nanofitins, which are derived from a protein found in Sulfolobus acidocaldarius—an archaeal microorganism found in hot springs—successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, ...
Bio & Medicine
Aug 30, 2023
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A new study reveals an important discovery in the realm of nanomachines within living systems. Prof. Sason Shaik from the Hebrew University of Jerusalem and Dr. Kshatresh Dutta Dubey from Shiv Nadar University, conducted ...
Bio & Medicine
Aug 7, 2023
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A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures. The method, published in Nature Nanotechnology, employs innovative nanopore technology ...
Bio & Medicine
Aug 1, 2023
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One of the main ways cells "talk" to each other to coordinate essential biological activities such as muscle contraction, hormone release, neuronal firing, digestion and immune activation is through calcium signaling.
Bio & Medicine
Jul 10, 2023
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Researchers have demonstrated significant improvements for chip-based sensing devices used to detect or analyze substances. The achievements lay the groundwork for highly sensitive portable integrated optofluidic sensing ...
Bio & Medicine
Jun 22, 2023
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Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane ...
Bio & Medicine
Jun 19, 2023
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Identifying whether and how a nanoparticle and protein will bind with one another is an important step toward being able to design antibiotics and antivirals on demand, and a computer model developed at the University of ...
Bio & Medicine
Jun 5, 2023
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The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases ...
Bio & Medicine
May 26, 2023
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