Decoding mystery sequences involved in gene regulation

Every cell in an organism's body has the same copy of DNA, yet different cells do different things; for example, some function as brain cells, while others form muscle tissue. How can the same DNA make different things happen? ...

The TALE of new tools to study gene regulation

In nearly every organism's genome, scattered between genes that encode proteins, long regulatory regions stretch across expanses of DNA. Understanding what role these so-called enhancer regions play in controlling the activation ...

Human Argonaute proteins: To slice or not to slice?

What makes one Argonaute a slicer and another one not? Human Argonaute proteins are key players in the gene regulation process known as RNA interference, RNAi. Professor Joshua-Tor's group of Cold Spring Harbor Laboratory ...

Selectively manipulating protein modifications

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology ...

Researchers learn from nature

A research team of scientists from the European Molecular Biology Laboratory of Grenoble and the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg have now, for the first time, succeeded ...

Scientists shed light on the 'dark matter' of DNA

In each cell, thousands of regulatory regions control which genes are active at any time. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a method that reliably detects these regions ...

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