A study has solved a long-standing debate about the transport of essential proteins, implicated in many human diseases, through one of the cell's most complex and sophisticated structures.
Molecular & Computational biology
May 4, 2020
0
255
An interdisciplinary team from the University of Basel in Switzerland has succeeded in creating a direct path for artificial nanocontainers to enter into the nucleus of living cells. To this end, they produced biocompatible ...
Bio & Medicine
Jan 27, 2020
0
462
Standing guard between a cell's nucleus and its main chamber, called the cytoplasm, are thousands of behemoth protein structures called nuclear pore complexes, or NPCs. NPCs are like the bouncers of a cell's nucleus, tightly ...
Cell & Microbiology
Jun 13, 2018
0
119
Cells can avoid "data breaches" when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert ...
Biochemistry
Mar 27, 2018
0
183
Like an island nation, the nucleus of a cell has a transportation problem. Evolution has enclosed it with a double membrane, the nuclear envelope, which protects DNA but also cuts it off from the rest of the cell. Nature's ...
Cell & Microbiology
Mar 15, 2018
0
126
Cells secure DNA within their nuclei like a secret code stashed in a vault. However, the tightly controlled borders of the nucleus create a challenge: In order for the cell to produce essential proteins, messages derived ...
Cell & Microbiology
Nov 11, 2016
0
701
Using an ultra fast-scanning atomic force microscope, a team of researchers from the University of Basel has filmed "living" nuclear pore complexes at work for the first time. Nuclear pores are molecular machines that control ...
Bio & Medicine
May 2, 2016
0
17
Caltech scientists have produced the most detailed map yet of the massive protein machine that controls access to the DNA-containing heart of the cell.
Biochemistry
Apr 15, 2016
0
2157
Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have uncovered new clues to how a molecular machine inside the cell acts as a gatekeeper, allowing some molecules to enter ...
Cell & Microbiology
Nov 6, 2015
1
81
A cell does everything it can to protect its nucleus, where precious genetic information is stored. That includes controlling the movement of molecules in and out using gateways called nuclear pore complexes (NPCs).
Cell & Microbiology
Sep 18, 2015
2
146
