(PhysOrg.com) -- Biologists led by associate professor Thomas Schwartz (MIT) have worked out a rudimentary architectural plan for the nuclear pore complex (NPC), the gatekeeper of the cell's nucleus.
Cell & Microbiology
Oct 27, 2009
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A study has solved a long-standing debate about the transport of essential proteins, implicated in many human diseases, through one of the cell's most complex and sophisticated structures.
Molecular & Computational biology
May 4, 2020
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255
Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have uncovered new clues to how a molecular machine inside the cell acts as a gatekeeper, allowing some molecules to enter ...
Cell & Microbiology
Nov 6, 2015
1
81
It was a 3D puzzle with over 1000 pieces, with only a rather fuzzy outline as a guide. But scientists at EMBL have now put enough pieces in place to see the big picture. In a study published today in Science, they present ...
Cell & Microbiology
Apr 15, 2016
5
62
Context matters. It's true for many facets of life, including the tiny molecular machines that perform vital functions inside our cells.
Molecular & Computational biology
Oct 13, 2021
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891
Cells have devised many structures for transporting molecular cargo across their protective borders, but the nuclear pore complex, with its flower-like, eight-fold symmetry, stands out. Monstrously large by cellular standards, ...
Cell & Microbiology
Jun 5, 2015
1
885
Like an island nation, the nucleus of a cell has a transportation problem. Evolution has enclosed it with a double membrane, the nuclear envelope, which protects DNA but also cuts it off from the rest of the cell. Nature's ...
Cell & Microbiology
Mar 15, 2018
0
126
(PhysOrg.com) -- UC Berkeley researchers Karsten Weis, Jan Liphardt, and colleagues have used fluorescent probes called quantum dots to determine which molecules get into the nucleus via its nano-pores and which get kicked ...
Bio & Medicine
Sep 2, 2010
1
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Cells can avoid "data breaches" when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert ...
Biochemistry
Mar 27, 2018
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183
A cell does everything it can to protect its nucleus, where precious genetic information is stored. That includes controlling the movement of molecules in and out using gateways called nuclear pore complexes (NPCs).
Cell & Microbiology
Sep 18, 2015
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