Bears' seasonal hibernation linked to changes in gut microbes

Each year, as bears prepare to hibernate, they gorge themselves on food to pack on fat. And yet, despite the rapid weight gain, the animals somehow avoid the health consequences so often associated with obesity in humans. ...

Fat turns from diabetes foe to potential treatment

A new weapon in the war against type 2 diabetes is coming in an unexpected form: fat. Researchers have discovered a new class of potentially therapeutic lipids, called fatty-acid esters of hydroxy fatty acids (FAHFAs). These ...

Hippo 'crosstalk' may be vital to tumor suppression

Think of a waterfall, and you might see why cell-signaling pathways are important to cancer research. As water cascades, it impacts everything downstream. And everything upstream affects the waterfall.

Protein essential for maintaining beta cell function identified

Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is ...

Researchers map new metabolic pathway involved in cell growth

Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular ...

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