A versatile, integrated workflow for interaction proteomics

Proteins do not function in isolation, and their interactions with other proteins define their cellular functions. Therefore, detailed understanding of protein-protein interactions (PPIs) is the key for deciphering regulation ...

Cells stressed out? Make mitochondria longer

Scientists at The Scripps Research Institute (TSRI) have discovered a new pathway in cells that promotes mitochondrial function during times of stress, a response that can guard against disease as we age.

Researchers discover mitochondria-to-nucleus messenger protein

Researchers have identified a protein, G-Protein Pathway Suppressor 2 (GPS2), that moves from a cell's mitochondria to its nucleus in response to stress and during the differentiation of fat cells. While proteins with similar ...

Mapping biological functions of NUDIX enzymes

In a large multidisciplinary project, researchers at Karolinska Institutet have explored different properties of an enzyme family called NUDIX hydrolases. The study, published in Nature Communications, reveals novel insights ...

Understanding key enzyme's role in embryonic development

The catalytic activity of an enzyme called Set1A—a protein that is essential to the viability of embryonic stem cells (ESCs)—is not required for ESC self-renewal, according to a Northwestern Medicine study published in ...

Maximum precision in protein synthesis

Researchers from the Center for Molecular Biology of Heidelberg University (ZMBH) and the German Cancer Research Center (DKFZ) have investigated the mode of action of a molecular chaperone vital to protein synthesis. Together ...

Chromosome motor discovery supports DNA loop extrusion

It is one of the great mysteries in biology: How does a cell neatly distribute its replicated DNA between two daughter cells? For more than a century, we have known that DNA in the cell is comparable to a plate of spaghetti—a ...

Chemists explained the origin of the green fluorescence

Researchers at the Lomonosov Moscow State University in cooperation with Danish molecular physicists have revealed the mechanism that determines the sensitivity of green fluorescent protein to light exposure. The scientists ...

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