Before DNA can be transcribed into RNA, an early step in turning the genetic template into protein, the nucleus must first assemble a molecular machine called the pre-initiation complex (PIC), capable of unzipping the double ...
Cell & Microbiology
Dec 2, 2014
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For 10 years, Patrick Cramer and his colleagues at Ludwig-Maximilians-Universitaet (LMU) in Munich have probed the structure of RNA polymerase I, a crucial cog in the machinery of all cells. Now they unveil the full three-dimensional ...
Cell & Microbiology
Oct 24, 2013
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(Phys.org) —In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism. ...
Biochemistry
Apr 9, 2013
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An team of Rutgers University scientists led by Richard H. Ebright and Eddy Arnold has determined the three-dimensional structure of the transcription initiation complex, the key intermediate in the process by which cells ...
Cell & Microbiology
Oct 18, 2012
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(Phys.org) -- When genetic information is read from the genetic blueprint DNA, RNA polymerase II translates it into RNA molecules. The C-terminal domain, abbreviated as CTD, is an important area of the polymerase molecule. ...
Biotechnology
May 21, 2012
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Indiana University biologists have found that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can differ in function based on variation in the parts -- in this case protein subunits ...
Biotechnology
Mar 1, 2012
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Gene transcription is central to cell function, as it converts the information stored in the DNA into RNA molecules of defined sequence, which then program protein synthesis. The enzyme RNA polymerase II (Pol II) is responsible ...
Cell & Microbiology
Feb 23, 2011
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