Molecules change shape when wet

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers led by Melanie Schnell from the Max Planck Institute for the Structure and Dynamics of Matter at ...

A practical synthesis for benzazetidine compounds

(Phys.org)—A key chemical component to antibiotics, such as penicillin is the beta-lactam, a four-membered amide ring that is fused to another heterocycle. Researchers in drug design would like to explore compounds using ...

Sensing small molecules may revolutionize drug design

Most pharmaceutical drugs consist of tiny molecules, which target a class of proteins found on the surfaces of cell membranes. Studying these subtle interactions is essential for the design of effective drugs, but the task ...

One step closer to cheaper antivenom

Researchers involved in an international collaboration across six institutions, including the University of Copenhagen and the National Aquarium of Denmark (Den Blå Planet), have successfully identified the exact composition ...

Structural discoveries could aid in better drug design

F. Scott Fitzgerald once said that the test of a first-rate intelligence is the ability to hold two opposed ideas in mind at the same time and still retain the ability to function. Now, scientists from the Florida campus ...

Research could help point the finger at drug dealers

An innovative technology pioneered by Sheffield Hallam University academics can detect the presence of a range of illegal and designer drugs from a single fingerprint, which could be a valuable new tool in bringing drug dealers ...

How do you make a greasy protein?

Every cell is encapsulated and protected by a thin membrane made of greasy molecules called lipids. Assemblies of equally greasy protein molecules span the membrane, forming passageways that control the flow of signaling ...

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