News tagged with drug candidate
Research team gives drug dropouts a second chance
(Phys.org) -- A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly ...
May 07, 2012 |
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Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologs while sparing paralogous pr
(Phys.org) -- New drug candidates require testing in animal models prior to approval for clinical use. A recently developed antagonist based on a bicyclic peptide inhibited the human serine protease plasma ...
Apr 13, 2012 |
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Biology-oriented synthesis (BIOS) - cancer drugs based on natural models
The search for new drug candidates for cancer treatment is laborious and time-consuming. Only a fraction of the promising chemical compounds identified completes the transition to the market. Herbert Waldmann ...
Feb 28, 2012 |
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Scientists develop new class of small molecules through innovative chemistry
Inspired by natural products, scientists on the Florida campus of the Scripps Research Institute have created a new class of small molecules with the potential to serve as a rich foundation for drug discovery.
Nov 20, 2011 |
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Rapid profiling of drug candidates
In the hunt for new medicines, any technique that expedites drug candidates into the clinic is a welcome advance. A team led by Hiroyuki Osada at the RIKEN Advanced Science Institute, Wako, recently developed ...
Chemistry / Analytical Chemistry
Sep 22, 2011 |
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Pfizer says patient died in oral RA drug study
(AP) -- Pfizer Inc. confirmed that one patient who was taking its drug candidate tofacitinib, a pill designed to treat rheumatoid arthritis, died during a recent clinical trial and said the death was connected to the drug.
Medicine & Health / Medications
Apr 22, 2011 |
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HIV-infected organs can save lives, doctors say
The nation has a huge need for kidneys, livers and other organs for transplant, but federal law has one absolute rule for donors: no HIV infections.
Apr 12, 2011 |
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Scientists discover a way to kill off tumors in cancer treatment breakthrough
Scientists from the School of Pharmacy at Queen's University Belfast and Almac Discovery Ltd have developed a new treatment for cancer which rather than attacking tumours directly, prevents the growth of new blood vessels ...
Apr 05, 2011 |
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Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cells
In what could be a potential breakthrough in the battle against AIDS and a major development in the rational design of new drugs, scientists have engineered a new protein that prevents the virus from entering cells. This ...
Mar 31, 2011 |
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Cytokinetics announces fundamental research in cardiac myosin activation
Cytokinetics, Inc. announced today the publication of preclinical research in the March 18, 2011 issue of the journal Science regarding the activation of cardiac myosin by an investigational drug candidate, omecamtiv mecarb ...
Medicine & Health / Medical research
Mar 17, 2011 |
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Modeling retinitis pigmentosa with iPS cells
Retinitis pigmentosa (RP) is a cluster of genetically determined eye disorders that cause visual defects such as night blindness and narrowing of the field of vision, due to progressive loss of rod photoreceptors. ...
Mar 09, 2011 |
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Scientists discover new compound that rids cells of Alzheimer protein debris
If you can't stop the beta-amyloid protein plaques from forming in Alzheimer's disease patients, then maybe you can help the body rid itself of them instead. At least that's what scientists from New York were ...
Mar 07, 2011 |
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Supercomputing research opens doors for drug discovery
A quicker and cheaper technique to scan molecular databases developed at the Department of Energy's Oak Ridge National Laboratory could put scientists on the fast track to developing new drug treatments.
Dec 09, 2010 |
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Researcher discovers way to overcome radiation resistance in leukemia
A team of researchers lead by Fatih M. Uckun, MD, PhD, of The Saban Research Institute of Childrens Hospital Los Angeles has determined that radiation resistance in leukemia can be overcome by selectively ...
Sep 30, 2010 |
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Promising new one-dose malaria drug discovered
Researchers have discovered a promising new malaria drug with the potential to treat resistant strains of the deadly disease in a single dose, according to a study published Thursday in the journal Science.
Medicine & Health / Medications
Sep 02, 2010 |
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