Without Dna2, genes can jump into DNA breaks

Cells have in place a number of mechanisms to protect the integrity of the genome, including processes that repair mistakes that may occur during DNA replication. The enzyme Dna2 participates in DNA repair, but little is ...

How invading jumping genes are thwarted

Since Carnegie Institution's Barbara McClintock received her Nobel Prize on her discovery of jumping genes in 1983, we have learned that almost half of our DNA is made up of jumping genes—called transposons. Given their ...

Clues from a Somalian cavefish about modern mammals' dark past

After millions of years living in constant darkness, a species of blind cavefish found only in Somalia has lost an ancient system of DNA repair. That DNA repair system, found in organisms including bacteria, fungi, plants, ...

CRISPR-based tool maps gene function in human cells

UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.

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