New research provides insight about the bedrock scientific principle that mitochondrial DNA—the distinct genetic code embedded in the organelle that serves as the powerplant of every cell in the body—is exclusively passed ...
Cell & Microbiology
Sep 18, 2023
0
356
Cannabidiol, popularly known as CBD, gained mainstream fame for treating seizures with a strain of hemp called "Charlotte's Web." It was named for Charlotte Figi, a child with Dravet syndrome whose family was so desperate ...
Veterinary medicine
Mar 3, 2020
0
7
About a decade ago, researchers in UC Santa Barbara chemistry professor Guillermo Bazan's lab began to observe a recurring challenge in their research: Some of the compounds they were developing to harness energy from bacteria ...
Cell & Microbiology
Feb 21, 2024
0
252
One surprising star of the coronavirus pandemic response has been the molecule called mRNA. It's the key ingredient in the Pfizer and Moderna COVID-19 vaccines. But mRNA itself is not a new invention from the lab. It evolved ...
Biotechnology
Apr 12, 2021
0
89
A new compound which visualises and kills antibiotic resistant superbugs has been discovered by scientists at the University of Sheffield and Rutherford Appleton Laboratory (RAL).
Bio & Medicine
May 28, 2019
0
3676
An alternative statistical method honed and advanced by Cornell researchers can make clinical trials more reliable and trustworthy while also helping to remedy what has been called a "replicability crisis" in the scientific ...
Mathematics
Dec 21, 2021
0
293
NAD, or nicotinamide adenine dinucleotide, probably needs no introduction. Together with its primary alter-egos NADH, NADP and NADPH, our private suite of pyridine-based nucleotides serve as hydride donors in some 400 enzymatic ...
Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. As a proof of concept, the ...
Bio & Medicine
Jun 16, 2021
0
1306
A research collaboration between Tufts University and the Chinese Academy of Sciences has led to the development of a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver, according ...
Bio & Medicine
Jul 12, 2019
0
576
A team of biochemists and virologists at Goethe University and the Frankfurt University Hospital were able to observe how human cells change upon infection with SARS-CoV-2, the virus causing COVID-19 in people. The scientists ...
Cell & Microbiology
May 14, 2020
8
2640
In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.
Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.
Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization
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