A not-so-selfish 'genetic parasite' helps to preserve fertility

Ribosomal DNA (rDNA) sequences are essential parts of many species' genomes. The highly repetitive nature of these DNA sequences makes them susceptible to shrinkage over time—and if they shrink too much, cells die. If rDNA ...

A protein hidden in plain sight helps cells time their escape

When a cell is getting ready to divide, it needs to duplicate its DNA, which is divided among its chromosomes, and arrange the chromosomes so that each new cell gets one complete set. If the chromosomes get sorted incorrectly, ...

Balance between proteins keeps sperm swimming swiftly

Sperm must swim swiftly to an egg in order to fertilize it, and so they have evolved hydrodynamic shapes. Most of the space in the head of sperm cells is taken up by the DNA they carry, so the cells coil up their DNA super ...

Learning how cells respond to stressful conditions

Developing approaches to protect human well-being in a changing climate will depend on a deeper understanding of how mammalian cells and organisms adapt to dramatic shifts in temperature and in the availability of food and ...

The not so inactive X chromosome

Nearly every cell in our body contains pairs of each of our chromosomes, and these pairs are identical in all but one case: that of our sex chromosomes. Males typically have one X and one Y sex chromosome, while females typically ...

Tracing a plant chemistry puzzle to its roots

Graduate student Colin Kim had been making good progress on a scientific puzzle that had fascinated him since he joined Whitehead Institute Member Jing-Ke Weng's lab, trying to understand how coumarin synthase (COSY), an ...

Abnormal RNA gums up the works in brain cells, shows study

Our DNA contains four types of molecules, adenine, cytosine, thymine, and guanine—called nucleotides or bases—running along the strands that make up our chromosomes. Since there are only four, it is not unusual to find ...

The immortality of germ cells

Germ cells, the reproductive cells that eventually become eggs and sperm, are set aside early in embryonic development, when the embryo is just a hollow ball of cells called the gastrula. This means that the cells transferring ...

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