Intercellular communication: From 'cable-phone' to 'cell-phone'?

Jul 08, 2010

Secreted microRNAs (miRNAs) from cells to blood maybe the novel class of signaling molecules mediating intercellular/interorgan communication. A research article, published this week in Molecular Cell, reports that miRNA can be secreted from one type of cells and delivered into recipient cells, decreases targeted gene expression, thus, regulates recipient cell function.

MiRNAs are a class of naturally occurring small non-coding RNAs that have been linked to biological possesses and diseases development. In the previous study, Chen-Yu Zhang and colleagues reported that expression profile of circulating miRNAs in human and other animals are the novel class of biomarkers for diagnosis of cancer and other diseases. As the consequent work, the same research team has investigated the source of circulating miRMAs. Chen-Yu Zhang and colleagues demonstrate that cell selectively packages miRNA into microvesicles when cell responses to different stimuli. The selective packaging is an essential point of specificity of cellular secretion of miRNAs. The research team also demonstrates that these secreted miRNAs can be delivered into target cells and can modulate the biological functions of these cells via repression of miRNA target gene expression.

"Since their discovery in C. elegans 15 years ago, miRNAs have been implicated in a wide array of cellular and developmental processes. To date, more than 500 miRNAs are predicted to be expressed in humans and nearly 30% of genes are predicted to be regulated by miRNAs. The present study extends our understanding of the role of miRNAs by illustrating that miRNAs can be secreted and delivered into target cells and that these exogenous miRNAs can alter the of the recipient cells by modulating the expression of their ," said Chen-Yu Zhang. "From this point of view, secreted miRNAs represent a novel class of signaling molecules that play an important role in mediating cell-to-cell and organ-to-organ communication." Moreover, the and targeting of miRNAs establishes a highly regulated complex network under various physiological and pathophysiological conditions.

"Compared to classic cellular communications mediated by hormone/cytokine-receptor and antigen-antibody interactions that generally occur only in certain types of cells, involve a single or few molecules, and affect target cells in a "one-way" fashion, secreted miRNA-based cell communication has the potential to function for every type of cell, to deliver many types of miRNAs with each miRNA targeting multiple genes, and to affect in "two-way" or "multi-way" fashion. Investigating this secreted miRNA-mediated shift of cell communication from a "cable telephone" to "cell phone" fashion would help us to further understand the nature of biological signaling, discover novel mechanisms of disease and develop new therapeutic strategies," added by co-author Ke Zen.

Explore further: Molecular gate that could keep cancer cells locked up

More information: Zhang et al.: "Secreted monocytic miR-150 enhances targeted endothelial cell migration" Publishing in Molecular Cell, July 9th 2010.

Provided by Nanjing University School of Life Sciences

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Researchers discover how microRNAs control protein synthesis

Jul 09, 2007

While most RNAs work to create, package, and transfer proteins as determined by the cell’s immediate needs, miniature pieces of RNA, called microRNAs (miRNAs) regulate gene expression. Recently, researchers from the University ...

Blood 'fingerprints' for cancer

Sep 03, 2008

Serum microRNAs (miRNAs) can serve as biomarkers for the detection of diseases including cancer and diabetes, according to research published online this week in Cell Research. The findings pave the way for a revolutionary ...

New biomarker for raw milk quality detection

Jun 15, 2010

Strict milk quality tests had drawn a national attention throughout China in the wake of the baby formula milk powder contamination incident. The individual classic markers for milk quality control, particularly protein concentration, ...

Researchers Identify microRNA targets in C. elegans

Jan 10, 2010

MicroRNAs (miRNAs) are non-coding RNAs that impact almost every aspect of biology. In recent years, they have been strongly implicated in stem cell biology, tissue and organism development, as well as human conditions ranging ...

Tiny genes may increase cancer susceptibility

May 23, 2007

New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. Differences in certain miRNAs may predispose some individuals to develop cancer, say ...

Recommended for you

Molecular gate that could keep cancer cells locked up

Jul 31, 2014

In a study published today in Genes & Development, Dr Christian Speck from the MRC Clinical Sciences Centre's DNA Replication group, in collaboration with Brookhaven National Laboratory (BNL), New York, ...

The 'memory' of starvation is in your genes

Jul 31, 2014

During the winter of 1944, the Nazis blocked food supplies to the western Netherlands, creating a period of widespread famine and devastation. The impact of starvation on expectant mothers produced one of the first known ...

Sugar mimics guide stem cells toward neural fate

Jul 30, 2014

Embryonic stem cells can develop into a multitude of cells types. Researchers would like to understand how to channel that development into the specific types of mature cells that make up the organs and other structures of ...

User comments : 0