RNA on the move

Nov 26, 2009
This electron microscopy image (grey) shows the posterior pole of a Drosophila oocyte, and superimposed on it is a projection of the movement of oskar mRNA in this region, recorded from a different oocyte at the same developmental stage. During this one-minute recording, the RNA moved from starting points labelled red to endpoints labelled green, via trajectories shown in blue. Image credit: Ephrussi / EMBL

In the fruit fly Drosophila, oskar mRNA, which is involved in defining the animal’s body axes, is produced in the nuclei of nurse cells neighbouring the oocyte, and must be transported to the oocyte and along its entire length before being translated into protein.

Scientists in the group of Anne Ephrussi at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have visualized the molecular mechanism that underlies this localisation process. In a study published today in Cell, they showed for the first time that, upon export from the nucleus of nurse cells into the cytosol - the semifluid that surrounds a cell’s nucleus -RNA particles recruit two , kinesin and dynein, which transport the to its final location in the oocyte.

By combining immunofluorescence with electron microscopy imaging, the EMBL scientists were able to discriminate where different molecules critical for oskar mRNA transport are recruited, thus defining a hierarchy of RNA particle assembly. These findings not only increase our understanding of development, but could also shed light on processes underlying the function of and axons in neurons, and - which is implicated in learning and memory formation - as these also entail the transport and localised translation of RNA.

More information: Trucco, A., Gaspar, I. & Ephrussi, A. Assembly of Endogenous oskar mRNA Particles for Motor-Dependent Transport in the Drosophila Oocyte. Cell, 25 November 2009.

Provided by European Molecular Biology Laboratory (news : web)

Explore further: Fighting bacteria—with viruses

add to favorites email to friend print save as pdf

Related Stories

How nerve cells stay in shape

Jan 17, 2006

Nerve cells store and transmit information via special contact sites called synapses. Synapses also play a role in determining what we remember and what we forget. When we learn, both the structure and the ...

Getting wise to the influenza virus' tricks

May 04, 2008

Influenza is currently a grave concern for governments and health organisations around the world. The worry is the potential for highly virulent bird flu strains, such as H5N1, to develop the ability to infect humans easily. ...

A unique arrangement for egg cell division

Aug 09, 2007

Which genes are passed on from mother to child is decided very early on during the maturation of the egg cell in the ovary. In a cell division process that is unique to egg cells, half of the chromosomes are eliminated from ...

Recommended for you

Fighting bacteria—with viruses

Jul 24, 2014

Research published today in PLOS Pathogens reveals how viruses called bacteriophages destroy the bacterium Clostridium difficile (C. diff), which is becoming a serious problem in hospitals and healthcare institutes, due to its re ...

Atomic structure of key muscle component revealed

Jul 24, 2014

Actin is the most abundant protein in the body, and when you look more closely at its fundamental role in life, it's easy to see why. It is the basis of most movement in the body, and all cells and components ...

Brand new technology detects probiotic organisms in food

Jul 23, 2014

In the food industr, ity is very important to ensure the quality and safety of products consumed by the population to improve their properties and reduce foodborne illness. Therefore, a team of Mexican researchers ...

Protein evolution follows a modular principle

Jul 23, 2014

Proteins impart shape and stability to cells, drive metabolic processes and transmit signals. To perform these manifold tasks, they fold into complex three-dimensional shapes. Scientists at the Max Planck ...

Report on viruses looks beyond disease

Jul 22, 2014

In contrast to their negative reputation as disease causing agents, some viruses can perform crucial biological and evolutionary functions that help to shape the world we live in today, according to a new report by the American ...

User comments : 0