A potential new imaging agent for early diagnosis of most serious skin cancer

Sep 30, 2009
Scientists are reporting development and testing of a potential new material for diagnosing malignant melanoma, the most serious form of skin cancer. Shown is an image of melanoma on a patient’s skin. Credit: Wikimedia Commons

Scientists in Australia are reporting development and testing in laboratory animals of a potential new material for diagnosing malignant melanoma, the most serious form of skin cancer. Their study is scheduled for the September 10 issue of the ACS' Journal of the Medicinal Chemistry.

Ivan Greguric and colleagues working within the Cooperative Research Consortium for Develop, an Australian Government funded research group, note that about 130,000 new cases of malignant occur each year worldwide. Patients do best with early diagnosis and prompt treatment. The positron (PET) scans sometimes used for diagnosis sometimes miss small cancers, delaying diagnosis and treatment.

The scientists' search for better ways of diagnosis led them to a new group of radioactive imaging agents, called fluoronicotinamides, which they tested in laboratory mice that had melanoma. The most promising substance revealed melanoma cells with greater accuracy than imaging agents now in use, the scientists note. As a result, this substance could become a "superior" PET imaging agent for improving the diagnosis and monitoring the effectiveness of treatment of melanoma, they say. Clinical trials with this new agent are now scheduled for 2010.

More information: "Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance", Journal of the Medicinal Chemistry

Source: American Chemical Society (news : web)

Explore further: Major step forward in understanding of viruses as scientists unlock exact structure of Hep A virus

add to favorites email to friend print save as pdf

Related Stories

Tiny delivery system with a big impact on cancer cells

Dec 15, 2008

Researchers in Pennsylvania are reporting for the first time that nanoparticles 1/5,000 the diameter of a human hair encapsulating an experimental anticancer agent, kill human melanoma and drug-resistant breast ...

Recommended for you

New insights on carbonic acid in water

9 hours ago

Though it garners few public headlines, carbonic acid, the hydrated form of carbon dioxide, is critical to both the health of the atmosphere and the human body. However, because it exists for only a fraction ...

User comments : 0