Sex, genes, the Y chromosome and the future of men

November 14, 2014 by Jenny Graves, The Conversation
The human Y chromosome has retained only 3% of its ancestral genes. So why’s it a shadow of its former self? Credit: Rafael Anderson Gonzales Mendoza/Flickr, CC BY-NC-SA

The Y chromosome, that little chain of genes that determines the sex of humans, is not as tough as you might think. In fact, if we look at the Y chromosome over the course of our evolution we've seen it shrink at an alarming rate.

So will it one day completely disappear? And what happens to the race if it does? It's a topic that's long been debated and we've covered before – but a paper published in Nature this year suggests the degradation of the chromosome has stabilised.

Humans, like other mammals, have what's called "chromosomal ". Women have two copies of a medium-sized chromosome called X (which stands for "unknown" because it was originally a mystery). Males have a single X and a tiny Y.

The X bears about 1,600 with varied functions. But the Y has hardly any genes; maybe 50, and only 27 of these are in the male-specific part of the Y. Many are present in multiple copies, most of them inactive, lying in giant loops of DNA. Most of the Y is made of repetitive "junk DNA". Thus the human Y shows all the signs of a degraded chromosome near the end of its life.

But the Y must contain a gene that determines maleness, because XXY people are male, and XO people with a single X but no Y are female.

We know that at 12 weeks an XY human embryo develops testes, which make male hormones and cause a baby to develop as a male. The identity of this male-determining gene on the Y – the SRY gene – was discovered in 1990 by a young Australian postdoc Andrew Sinclair (a PhD graduate from my lab). Babies with mutations in the SRY gene don't develop testes, and develop as females.

Sex in other vertebrates

Leave humans for a moment, and you see a huge variety of sex systems.

Some reptiles, fish and frogs are XX female: XY male like humans, but have different sex genes. Other vertebrates, such as birds and snakes, are just the opposite, with ZZ males and ZW females, and the sex gene is different again.

Many reptiles and some fish use environmental cues (usually temperature) rather than genetic triggers to determine sex.

So we are wrong if we think sex determination in human babies is typical of vertebrates.

Credit: Jenny Graves, Author provided

The degrading human Y

But back in the world of humans: what befell the Y to make it so much smaller than the X and lose most of its genes?

Our sex were once just a pair of ordinary chromosomes, which they still are in birds and reptiles. We found they are still ordinary chromosomes even in monotreme mammals (platypuses and echidnas) which last shared a common ancestor with humans 166 million years ago.

This means that within the past 166 million years the human Y lost most of its 1,600-odd genes, a rate of nearly 10 per million years.

At this rate, the Y chromosome will disappear in about 4.5 million years. This back-of-the-envelope calculation, inserted as a throwaway line in a little paper in 2002, produced a hysterical reaction and loads of responses. When I talk about the disappearing Y, men in the audience shrink into their seats to protect their manhood.

But why the surprise? Degradation is typical of all sex chromosome systems. Acquisition of a gene that determines sex is the kiss of death for a chromosome, because other genes nearby on the Y evolve a male-specific function, and these genes are kept together by suppressing exchange with the X.

This means that the Y can't get rid of mutations or deletions or invading junk DNA by swapping good bits with the X.

The poor Y chromosome is also at a disadvantage because it is in the testis every generation. This is a dangerous place to be because cells must divide many times to make sperm, so mutations are much more frequent.

Has the human Y stabilised?

Of course, the loss of genes from the Y is unlikely to be linear. It could get faster as the Y becomes more unstable, or it could stabilize as the Y is stripped to essential genes.

Biologist David Page's group from Boston keenly defend the honour of the human Y, noting that although chimpanzees have lost a few genes since we shared a 5 million years ago, humans haven't. In fact, humans have lost very few genes in the 25 million years since we diverged from monkeys.

So has the human Y finally stabilised? Maybe loss of any of the remaining 27 Y genes would compromise the viability, or fertility of the bearer. A 2014 paper from Page's group claiming that the Y is here to stay has unleashed another round of debate, recently aired on US National Public Radio (NPR).

Credit: _marmota/Flickr, CC BY-NC-SA

But looking more widely reveals that even genes on the human Y with important functions (such as making sperm) are missing from the mouse Y, and vice versa.

Most spectacularly, species in two rodent groups have lost their entire Y chromosome. Y genes have been either shunted to other chromosomes, or replaced – we don't know by what. So it must be possible to dispense with the Y and start over again.

A world without men?

If the human Y disappears, will men disappear? If they do, that'll be the end of the human race. We can't become a female-only species (as have some lizards, such as the New Mexico whiptail) because there are at least 30 "imprinted" genes that are active only if they come through the sperm. So we can't reproduce without men.

So does that mean humans will become extinct in 4.5 million years? Not necessarily. The Y-less rodents have evolved a new sex determining gene, so why not humans?

Three species of whiptail: little striped whiptail, ( Cnemidophorus inornatus), New Mexico whiptail (C. neomexicanus) and western whiptail (C. tigris). Credit: Alistair J. Cullum/Wikimedia Commons, CC BY

Perhaps this has already happened in some small isolated population, where genetic accidents are much more likely to take hold. We wouldn't know without screening chromosomes from every human population on the planet.

But a group of humans with new sex determining genes won't easily breed with humans who retain the present XY system. Children of, say, an XX woman and a man with a novel sex gene, are likely to be intersex or at least infertile. Such a reproductive barrier can drive incipient species apart, as happened with Y-less rodents. So if we return to Earth in 4.5 million years, we might find either no humans – or several different hominid species.

In any case, 4.5 million years is a long time. We have been human for less than 100,000 years. And I can think of several ways in which we are likely to become extinct long before we run out of Y chromosome.

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not rated yet Nov 14, 2014
From the article:
The X bears about 1,600 genes with varied functions. But the Y has hardly any genes; maybe 50, and only 27 of these are in the male-specific part of the Y.
From WIkipedia:
The X chromosome contains about 2000 genes compared to the Y chromosome containing 78 genes.
From Genetics Home Reference:
The X chromosome likely contains 800 to 900 genes that provide instructions for making proteins.
And so on...

These results lead me to believe that the number of genes on the chromosomes must vary greatly from individual to individual. It these results were reported by different sources working on the same genome, then the technology is in question, so what do we really know?
not rated yet Nov 14, 2014
...and Monotremes have 11 sex chromosomes.
not rated yet Nov 16, 2014
"So will it one day completely disappear? And what happens to the human race if it does? "

I would expect a science-oriented site not to use the word 'race' when it presumably means 'species'. The human species consists of several loosely defined races.

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