Nanoparticles replace needle and thread

April 28, 2014
Wound closure and organ repair with nanoparticle solutions

(Phys.org) —Stopping bleeding, closing wounds, repairing organs—these are everyday challenges in medical and surgical practice. In the journal Angewandte Chemie, French researchers have now introduced a new method that employs gluing by aqueous nanoparticle solutions to effectively control bleeding and repair tissues. In animal tests, their approach proved easy to apply, rapid and efficient even in situations when conventional methods are traumatic or fail.

Sutures and staples are efficient tools for use in surgery and treating . However, the usefulness of these methods can be limited in inaccessible parts of the body or in minimally invasive surgeries. In addition, stitching damages soft tissues such as liver, spleen, kidney, or lung. A good adhesive could be a useful alternative. The problem is that the adhesion must take place in a wet environment and that the repaired area is immediately put under strain. Previous adhesive technologies have had problems, including insufficient strength, inflammation due to toxic substances, or complicated implementation because a chemical polymerization or cross-linking reaction must be carried out in a controlled manner.

A team headed by Ludwik Leibler at the Laboratoire Matière Molle et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur at the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Université Paris Diderot) has now successfully tested a completely novel approach for adhering living tissue: they simply apply droplets of a nanoparticle solution to the wound and press it closed for about a minute. The principle behind is stunningly simple: the spread out across the surface and bind to the tissue's molecular network by attracting interactions. Because there are a very large number of nanoparticles present, millions of bonds firmly bind the two surfaces together. No chemical reaction is needed. The researchers used silicon dioxide and for their experiments.

In contrast to conventional wound adhesives, this results in no artificial barrier; it produces direct contact between the two edges of the wound. Because the nanoparticles are so small, they do not appreciably impact the wound healing process. Applied to deep skin wounds the method is easily usable and leads to remarkably aesthetic healing. In addition, it is possible to correct the positioning of the tissue edges relative to each other without opening the wound closure.

Aqueous solutions of nanoparticles have been also shown to be able to repair rapidly and efficiently in hemorrhagic conditions liver wounds for which sutures are traumatic and not practical. Either a wound was closed and wound edges were glued by nanoparticles or, in the case of liver resections, bleeding was quickly stopped by gluing a polymer strip using a nanoparticle solution.

In addition, the researchers were able to attach a biodegradable membrane to a beating rat heart. This opens new perspectives: it may be possible to attach medical devices for delivering drugs, supporting damaged tissue, as well as matrices for tissue growth.

Explore further: Mussels inspire innovative new adhesive for surgery

More information: Ludwik Leibler. "Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles." Angewandte Chemie International Edition, dx.doi.org/10.1002/anie.201401043

Related Stories

Mussels inspire innovative new adhesive for surgery

January 9, 2013

(Phys.org)—Mussels can be a mouthwatering meal, but the chemistry that lets mussels stick to underwater surfaces may also provide a highly adhesive wound closure and more effective healing from surgery.

Revolutionary method for gluing gels and biological tissues

December 12, 2013

Researchers have discovered an efficient and easy-to-use method for bonding together gels and biological tissues. A team of French researchers has succeeded in obtaining very strong adhesion between two gels by spreading ...

Innovative strategy to facilitate organ repair

April 18, 2014

A significant breakthrough could revolutionize surgical practice and regenerative medicine. A team led by Ludwik Leibler from the Laboratoire Matière Molle et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur from the ...

Recommended for you

Making nanowires from protein and DNA

September 3, 2015

The ability to custom design biological materials such as protein and DNA opens up technological possibilities that were unimaginable just a few decades ago. For example, synthetic structures made of DNA could one day be ...

Graphene made superconductive by doping with lithium atoms

September 2, 2015

(Phys.org)—A team of researchers from Germany and Canada has found a way to make graphene superconductive—by doping it with lithium atoms. In their paper they have uploaded to the preprint server arXiv, the team describes ...

For 2-D boron, it's all about that base

September 2, 2015

Rice University scientists have theoretically determined that the properties of atom-thick sheets of boron depend on where those atoms land.

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

ForFreeMinds
1 / 5 (1) Apr 28, 2014
While this is a promising discovery, it seems to me the writer is in error stating:

"The principle behind is stunningly simple: the nanoparticles spread out across the surface and bind to the tissue's molecular network by attracting interactions. Because there are a very large number of nanoparticles present, millions of bonds firmly bind the two surfaces together. No chemical reaction is needed."

Isn't the binding of particles to molecules a "chemical reaction"? If not, how does one distinguish between these bonds, and bonds produced by chemical reactions?

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.