New cranial neural crest cell line developed

Sep 19, 2012
©2012, Mary Ann Liebert Inc., publishers

Researchers have successfully developed a stable population of neural crest cells derived from mice that can be grown in large quantities in the laboratory and that demonstrates the potential to develop into many different cell types needed throughout the body. This powerful new research tool for understanding stem cell biology and human development and disease is described in an article published in Stem Cells and Development.

Mamoru Ishii and colleagues from University of Southern California, Los Angeles, and California Institute of Technology, Pasadena, CA, present their work leading to the development of two neural crest cell lines with stem cell characteristics in the article "A Stable Cranial Neural Crest Cell Line from Mouse." The 09-1 cell line is capable of differentiating into four main cell types: bone, muscle, brain, and cartilage/connective tissue.

"This exciting report is the first to characterize cranial neural crest cell lines isolated from the , which definitively demonstrate multipotency and long-term propagation," says Editor-in-Chief Graham C. Parker, PhD, research professor, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine.

Explore further: Sugar mimics guide stem cells toward neural fate

add to favorites email to friend print save as pdf

Related Stories

What decides neural stem cell fate?

May 05, 2011

Researchers at Sanford-Burnham Medical Research Institute and their collaborators found that expression of a gene called SOX2 maintains the potential for neural crest stem cells to become neurons in the peripheral nervous ...

New study hopeful on neural stem cells

Aug 05, 2006

Neural stem cells derived from federally approved human embryonic cells are inferior to stem cells derived from donated fetal tissue, a new study found.

Recommended for you

Sugar mimics guide stem cells toward neural fate

17 hours ago

Embryonic stem cells can develop into a multitude of cells types. Researchers would like to understand how to channel that development into the specific types of mature cells that make up the organs and other structures of ...

Researchers uncover secrets of internal cell fine-tuning

Jul 29, 2014

New research from scientists at the University of Kent has shown for the first time how the structures inside cells are regulated – a breakthrough that could have a major impact on cancer therapy development.

User comments : 0