Biologist discovers mammal with salamander-like regenerative abilities

Sep 26, 2012 by Donna Hesterman
African spiny mouse specimen collected in the field near Nairobi Kenya. Credit: Ashley Seifert

(Phys.org)—A small African mammal with an unusual ability to regrow damaged tissues could inspire new research in regenerative medicine, a University of Florida study finds.

For years biologists have studied for their ability to regrow lost limbs. But amphibian biology is very different than human biology, so lessons learned in laboratories from salamanders are difficult to translate into medical therapies for humans. New research in the Sept. 27 issue of the journal Nature describes a mammal that can regrow new body tissues following an injury. The African spiny mouse could become a new model for research in regenerative medicine.

"The African spiny mouse appears to regenerate ear tissue in much the way that a salamander regrows a limb that has been lost to a predator," said Ashley W. Seifert, a postdoctoral researcher in UF's biology department. "Skin, hair follicles, cartilage—it all comes back."

That's not the case in other mammals, he said. Usually forms to fill the gap created by a wound.

The spiny mouse also regrows tissue on its main body when injured but not as completely as it does in its ears. "On their backs, they regrow hair follicles and skin, but the muscle beneath the skin doesn't regenerate," Seifert said.

Seifert was studying scar-free healing in amphibians when a colleague told him that a small rodent he had observed in Africa seemed capable of autotomy, a whereby the animal self-amputates a body part to escape a predator.

"Autotomy in skinks, and some salamanders is well known," Seifert said. "But it is very rare in mammals, and so far we've only seen it in a few rodents that can jettison their tail."

Seifert's colleague said that the African spiny mouse appeared to have tear-away skin that allowed it to slip a predator's grasp. The notion was interesting enough to send Seifert packing to the Mpala Research Centre near Nairobi, Kenya.

In Nairobi, Seifert was able to document the first known case of skin autotomy in a mammal. But it was how the animals' injuries appeared to be healing that really got his attention.

Seifert used a 4mm biopsy punch, about the size of a large BB, to puncture holes in the ears of the mice to see if the animal showed regenerative capabilities.

"The results were astonishing," he said. "The various tissues in the ear grew back through formation of blastema-like structures—the same sort of biological process that a salamander uses to regenerate a severed limb."

Ken Muneoka, a Tulane University professor of cell and molecular biology who was not involved with the study, agrees that Seifert's findings are important.

"It could represent a new model system for wound healing and tissue regeneration in humans," he said.

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User comments : 6

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Sonhouse
3 / 5 (4) Sep 26, 2012
All that assuming it can transfer to humans. Big if there.
obama_socks
1 / 5 (6) Sep 26, 2012
Next question could be: did all ancestors of mice originate out of Africa as humans supposedly did?

Here's a link to a story that's nothing short of miraculous.

http://www.nydail....1167774
cantdrive85
1 / 5 (5) Sep 26, 2012
I used to run a deli slicer and lost some finger tips, they grew back. Why is this news?
Lantern5
1.7 / 5 (3) Sep 26, 2012
Waw. This can be great for a drug of "eternal life"
But the case is likely to be dependent on whether or not certain genes. Which is good for those who want to alter the DNA of her future children.
Birger
not rated yet Sep 27, 2012
(compulsory Monthy Python reference)
So that's why Spiny Norman was able to regenerate when Dinsdale Pirhana hit him with a tactical nuke...
alfie_null
not rated yet Sep 27, 2012
but the muscle beneath the skin doesn't regenerate

It seems like that would be an advantageous attribute. I'm curious about the reasons why such a trait didn't evolve.

It's interesting that out genes can mandate regeneration of specific parts of our bodies - it's not just all or nothing.