Oxford Nanopore announces groundbreaking GridION and MinION gene sequencers

February 20, 2012 by Bob Yirka report

(PhysOrg.com) -- Oxford University spinoff company, Oxford Nonopore has announced at this year’s Advances in Genome Biology and Technology conference in Florida, two new machines for sequencing genes. Of particular note is the MinION, a machine small enough to fit in the hand which can be plugged into a laptop’s USB port. The other, the GridION, is a larger version that can be stacked to increase processing power. Both rely on a technology known as strand sequencing whereby a nanopore (engineered protein) is used to pull strands of DNA through a hole where a microchip measures minute changes in the electrical current in the membrane around it as individual bases, or pairs are pulled through. Because of the way it is done, much longer sections of DNA can be examined at once, doing away with the need to examine small sections independently and then knitting the results together with a computer afterwards.

Sequencing of genes is a process where the chemical order of units (T, C, G and A) are determined. Doing so helps researchers and doctors determine inherited traits in plants and animals. It is an area of science that has been in the news of late as it is a hotbed of excitement for investors. This announcement by Oxford Nonopore comes as rather a shock to the established players in the field, American companies, Illumina and Life Technologies.

In addition to their small size, the new devices are able to perform sequencing faster than previous machines. Representatives of Oxford Nonopore say if 20 units (adding up to roughly $5000) are connected together the GridION can sequence an entire human genome in just fifteen minutes. In comparison, Life Technologies’ latest product, the Ion Proton Sequencer, at a price of almost $150,000, takes twenty four hours.

But it’s the MinION that is causing the most excitement in the scientific community. At just $900, any researcher anywhere could take a sample, in the field even, slip it into the device, then plug it into a laptop, and almost instantly have information about small genome samples. Seed research companies could use it to analyze crops in a field, for example, to see if they have mixed without outside sources, meat inspectors could use it test for different types of microorganisms, biologists could use it to look for small changes in genes over generations. The number of applications are literally too many to envision.

One dark spot in an otherwise rosy picture is the fact that the devices have a four percent error rate. Too high for many applications, though the company says it believes it can get the rate down significantly before the product is released sometime this year.

Explore further: Two new DNA sequencing methods unveiled

More information: Company's press release

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4 / 5 (1) Feb 20, 2012
A USB DNA sequencing device!???
Four percent error is very high though. I wonder if its possible to reduce the error by running a sample multiple times, or perhaps just by extending the run time.
not rated yet Feb 20, 2012
4 percent HA -- you know the error on the original human genome was way north of that number and it was considered complete.

The draft sequence covered 90 percent of the genome at an error rate of one in 1,000 base pairs, but there were more than 150,000 gaps and only 28 percent of the genome had reached the finished standard. In the April 2003 version, there are less than 400 gaps and 99 percent of the genome is finished with an accuracy rate of less than one error every 10,000 base pairs. The differences between the two versions are significant for scientists using the sequence to conduct research.

taken from http://www.genome.gov/11006943

5 / 5 (1) Feb 20, 2012
Wow, this is remarkable!

"if 20 units (adding up to roughly $5000) are connected together the GridION can sequence an entire human genome in just fifteen minutes."

The Human Genome Project cost about 3 billion dollars and took over 13 years to sequence a genome (roughly). Gattaca, here we come :)

5 / 5 (1) Feb 21, 2012
Those are some pretty awesome computer graphics...

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