BGI develops first monkey exome sequencing platform for biomedical research

October 11, 2011

BGI, the world's largest genomics organization, has developed the first exome sequencing platform for the monkey, based on next-generation sequencing technology and monkey exome capturing array (MECA). MECA is a proprietary exome capture array designed by BGI for capturing the entire monkey exome. The combination of this revolutionary array and BGI's high-throughput sequencing technology not only can simplify the workflow of exome sequencing experiments, but also improve cost-effectiveness and turnaround time.

Due to its close relationship genetically and physiologically to humans, the monkey is the most extensively used non-human primate in biomedical research and animal models for human disease research. Macaque monkeys, in particular, are commonly used in research. Each year, there are thousands of Macaques used in pre-clinical studies throughout the world, including studies of pathogenic mechanisms, drug selection, drug dosage, treatment duration and , among others.

"Considering the important significance of studying the genetic variations of Macaque monkeys, we initiated the Chinese (Macaca mulatta) genome project and Cynomolgus macaque (Macaca fascicularis) genome project," said Jiong Zhang, Technical Specialist at BGI. "Based on the genomic data generated from the two projects, BGI designed the exome capture array and developed the exome sequencing platform for the monkey to facilitate biomedical research."

Utilizing the monkey exome sequencing platform, researchers can access genomic regions of interest in their sequencing experiments. "The unique combination of MECA and next-generation sequencing allows researchers to understand efficiently the detailed genetics of monkeys. We believe our breakthrough will enable monkey exome sequencing to play a more important role in biomedical and ," Zhang added.

Explore further: Researchers assemble second non-human primate genome

Related Stories

Researchers assemble second non-human primate genome

February 9, 2006

A multi-center team has deposited the draft genome sequence of the rhesus macaque monkey into free public databases for use by the worldwide research community, the National Human Genome Research Institute (NHGRI), one of ...

Researchers sequence exomes of 12 people (w/ Video)

August 16, 2009

In a pioneering effort that generated massive amounts of DNA sequence data from 12 people, a team supported by the National Institutes of Health (NIH) has demonstrated the feasibility and value of a new strategy for identifying ...

Recommended for you

Orangutan females prefer dominant, cheek-padded males

September 1, 2015

Unlike most mammals, mature male orangutans exhibit different facial characteristics: some develop large "cheek pads" on their faces; other males do not. A team of researchers studied the difference in reproductive success ...

Plastic in 99 percent of seabirds by 2050

August 31, 2015

Researchers from CSIRO and Imperial College London have assessed how widespread the threat of plastic is for the world's seabirds, including albatrosses, shearwaters and penguins, and found the majority of seabird species ...

Researchers unveil DNA-guided 3-D printing of human tissue

August 31, 2015

A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.