New delivery system for Viagra ingredient

Jun 22, 2011

Scientists are reporting development and successful initial tests of a potential new delivery system for the biological signaling agent responsible for the effects of Viagra. It could be used to deliver the substance, called nitric oxide or NO, to treatment conditions ranging from heart disease to skin ulcers and other wounds that fail to heal, according to a report in the Journal of the American Chemical Society.

Joao Rocha and colleagues explain that NO acts as an important agent in the body for expanding blood vessels (its role in Viagra and related medicines for erectile dysfunction), preventing the formation of blood clots, aiding , and repairing wounds. NO's multipurpose role makes it an exciting prospect for new drug development, but current NO delivery systems sometimes cause undesirable side effects. "Clearly, new materials and technologies are needed to store and target-deliver NO in biological amounts," the report notes.

The researchers developed a highly absorbent material that can carry varying amounts of NO. The material slowly releases NO at a rate that is useful for treating diseases, they conclude. More work must be done to calculate the "shelf life" of the material loaded with NO, Rocha and colleagues note, but they conclude: "This work is a first step toward assessing the real potential therapeutic applications of these materials."

Explore further: Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

More information: “Slow Release of NO by Microporous Titanosilicate ETS-4”, J. Am. Chem. Soc., 2011, 133 (16), pp 6396–6402
DOI: 10.1021/ja200663e

Abstract
A novel approach to designing nitric oxide (NO) storage and releasing microporous agents based on very stable, zeolite-type silicates possessing framework unsaturated transition-metal centers has been proposed. This idea has been illustrated with ETS-4 [Na9Si12Ti5O38(OH)·xH2O], a titanosilicate that displays excellent NO adsorption capacity and a slow releasing kinetics. The performance of these materials has been compared to the performance of titanosilicate ETS-10, [(Na,K)2Si5TiO13·xH2O], of benchmark zeolites mordenite and CaA, and of natural and pillared clays. DFT periodic calculations have shown that the presence of water in the pores of ETS-4 promotes the NO adsorption at the unsaturated (pentacoordinated) Ti4+ framework ions.

add to favorites email to friend print save as pdf

Related Stories

A better imaging agent for heart disease and breast cancer

Apr 27, 2011

Scientists are reporting development of a process for producing large quantities of a much-needed new imaging agent for computed tomography (CT) scans in heart disease, breast cancer and other diseases, and the first evidence ...

NanoViagra

Apr 28, 2009

(PhysOrg.com) -- A new generation of anti-impotency drugs based on nanoparticles might be coming quickly. Researchers at the Albert Einstein College of Medicine in New York presenting at the 104'th Annual Meeting ...

Viagra developer Furchgott dead at 92: report

May 24, 2009

Robert Furchgott, a Nobel prize-winning pharmacologist whose work with the gas nitric oxide helped develop the anti-impotency drug Viagra, has died at the age of 92, The New York Times reported Sunday.

Recommended for you

Researchers show fruit flies have latent bioluminescence

Apr 10, 2014

New research from Stephen C. Miller, PhD, associate professor of biochemistry and molecular pharmacology, shows that fruit flies are secretly harboring the biochemistry needed to glow in the dark—otherwise ...

User comments : 0

More news stories

Chemists achieve molecular first

(Phys.org) —Chemists from Trinity College Dublin have achieved a long-pursued molecular first by interlocking three molecules through a single point. Developing interlocked molecules is one of the greatest ...

Metals go from strength to strength

To the human hand, metal feels hard, but at the nanoscale it is surprisingly malleable. Push a lump of metal with brute force through a right-angle mould or die, and while it might look much the same to the ...

Low Vitamin D may not be a culprit in menopause symptoms

A new study from the Women's Health Initiative (WHI) shows no significant connection between vitamin D levels and menopause symptoms. The study was published online today in Menopause, the journal of The North American Menopa ...

Astronomers: 'Tilt-a-worlds' could harbor life

A fluctuating tilt in a planet's orbit does not preclude the possibility of life, according to new research by astronomers at the University of Washington, Utah's Weber State University and NASA. In fact, ...