WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells. The discovery could help to solve the mystery cause of a rare group of ...
Cell & Microbiology
Jan 10, 2022
0
96
The molecular mechanism underlying enzyme activity regulation of ubiquitin-specific protease 8 (USP8) has been decoded by researchers at Tokyo Tech. USP8 has been implicated in Cushing's disease pathogenesis. They have identified ...
Molecular & Computational biology
Nov 26, 2021
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73
A new paper by the Peter group of the ETH Zurich's Institute of Biochemistry (IBC) finds that the human GID E3 ubiquitin ligase forms a tetrameric complex with two distinct substrate-recruitment modules, namely WDR26-RanBP9 ...
Molecular & Computational biology
Oct 25, 2021
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12
Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control processes such as signal transduction and metabolism. Prof. Dr. ...
Cell & Microbiology
Jul 29, 2021
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1009
Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is located where two PCNA molecules ...
Cell & Microbiology
Jul 22, 2021
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12
St. Jude Children's Research Hospital scientists are studying the processes that enable cells to respond and adapt to environmental stress, many of which are also associated with neurodegenerative diseases. In complementary ...
Cell & Microbiology
Jun 25, 2021
1
18
A research group led by Prof. Hiroyasu Nakano at the Department of Biochemistry, Toho University Faculty of Medicine, identified Mind bomb-2 (MIB2) as an enzyme that ubiquitinates and modifies the protein cFLIP, which plays ...
Cell & Microbiology
Jan 27, 2021
0
5
UT Southwestern researchers have discovered a mechanism that cells use to degrade microRNAs (miRNAs), genetic molecules that regulate the amounts of proteins in cells.
Biotechnology
Nov 12, 2020
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234
In a new paper with results that senior author Eric Strieter at the University of Massachusetts Amherst calls "incredibly surprising," he and his chemistry lab group report that they have discovered how an enzyme known as ...
Cell & Microbiology
Nov 7, 2020
1
191
The phytohormone abscisic acid (ABA) is an important regulator in plant abiotic stress adaptation. The control of the co-receptor PP2C proteins like ABI1 is the central hub of ABA signaling transduction. Under standard conditions, ...
Molecular & Computational biology
Oct 20, 2020
0
4
