In a study published in PNAS, a research team has resolved the first high-resolution structure of the sgc8c DNA aptamer that targets protein tyrosine kinase 7 (PTK7), engineered two optimal sgc8c variants for disease theranostics ...
Molecular & Computational biology
Jul 19, 2024
0
32
An international research team used a common amino acid, tyrosine, packaged as a nanomedicine, to change the metabolism of melanoma, a deadly skin cancer, and prevent cancer growth.
Bio & Medicine
Jun 18, 2024
0
21
In the human body, molecules known as kinases propagate signals within and between cells, relaying signals that allow cells to respond to changes in the environment. However, there are hundreds of different kinases in the ...
Biochemistry
May 8, 2024
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130
Synthetic biologists from Rice University and Princeton University have demonstrated "live reporter" technology that can reveal the workings of networks of signaling proteins in living cells with far greater precision than ...
Cell & Microbiology
Jul 10, 2023
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589
A research study has shed new light on how congenital muscular dystrophies such as Walker-Warburg syndrome progress, bringing hope for better understanding, early diagnosis and treatments of these fatal disorders.
Molecular & Computational biology
Mar 10, 2023
0
233
A "non-essential" amino acid—so-called because the body can make it from other nutrients—can act as a nutritional cue to guide the body's responses to a low-protein diet, a RIKEN-led team has found in a study on fruit ...
Molecular & Computational biology
Oct 17, 2022
0
176
Kobe University researchers have successfully developed a tyrosine chassis (a strain of microorganism with high tyrosine productivity) in the yeast Pichia pastoris through rational engineering. In addition they used this ...
Biochemistry
Jun 10, 2022
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42
A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (U.S.) proposes a new strategy ...
Biochemistry
Jun 17, 2021
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8
Tyrosine phosphorylation (pTyr) can initiate cellular signaling and govern cellular functions. Its dysregulation is implicated in many diseases, especially cancers. Specific detection of pTyr-is important for developing targeted ...
Bio & Medicine
Sep 17, 2020
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6
A study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signalling complex, the study ...
Molecular & Computational biology
Oct 21, 2019
0
11
