Genetic 'hitchhikers' can be directed using CRISPR

In a new study, North Carolina State University researchers characterize a range of molecular tools to rewrite—not just edit—large chunks of an organism's DNA, based on CRISPR-Cas systems associated with selfish genetic ...

Biologists track DNA 'parasites' in the hunt for disease treatments

They are considered "parasitic genes." Even though they comprise over half of human DNA, much remains to be learned about them. Now University of California, Irvine biologists offer new insights into these entities known ...

How highly resistant strains of fungi emerge

An international research team has deciphered the mechanism by which the fungus Cryptococcus neoformans is resistant to fungus-specific drugs. It is a yeast-like fungus that can infect humans. Specific drugs, named antifungals, ...

When two worlds meet: A protease that controls small RNA activity

The protection of genome integrity of germ cells is essential for animal fertility. Researchers from the Grosshans group characterized a defense mechanism against selfish genetic elements in the C. elegans germline. They ...

Protecting the genome from transposon activation

Transposons are foreign DNA elements capable of random insertion into the genome, an event that can be very dangerous for a cell. Their activity must be silenced to maintain genomic integrity, which is primarily achieved ...

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