From molecule to medicine via machine learning

It typically takes many years of experiments to develop a new medicine. Although vaccines to protect against disease from the novel coronavirus are starting to reach clinics around the world, patients and doctors will still ...

Heating proteins to understand how genes work

Understanding how genes work and how they interact with one another is a major goal of biology. This poses huge challenges in terms of both methods and the sheer numbers of experiments required. Recent advances have transformed ...

A recipe for protein footprinting

Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins—that is, ...

Developing an AI solution to 50-year-old protein challenge

In a major scientific advance, the latest version of DeepMind's AI system AlphaFold has been recognized as a solution to the 50-year-old grand challenge of protein structure prediction, often referred to as the 'protein folding ...

Creating self-constructed folded macrocycles with low symmetry

The synthesis and self-organization of biological macromolecules is essential for life on earth. Ludwig Maximilian University of Munich chemists now report the spontaneous emergence of complex ring-shaped macromolecules with ...

Dual brake on transport protein prevents cells from exploding

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing. To counter this, bacteria can increase their internal solute concentration. Scientists from the University ...

Chemists discover the structure of a key coronavirus protein

MIT chemists have determined the molecular structure of a protein found in the SARS-CoV-2 virus. This protein, called the envelope protein E, forms a cation-selective channel and plays a key role in the virus's ability to ...

Peering under the hood of SARS-CoV-2

Information from electron microscope images and protein databases has been used to develop a detailed 3D model of SARS-CoV-2, which can be readily updated as new data becomes available. The modeling tool has potential for ...

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