Bicyclic protein mimetics inhibit the oncogene β-catenin

The inhibition of pathological protein–protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that ...

How reef-building corals got their bones

Coral reefs provide shelter, sustenance and stability to a range of organisms, but these vital ecosystems would not exist if not for the skeletal structure created by stony corals. Now, KAUST scientists together with an international ...

Lighting the way to folding next-level origami

Origami may sound more like art than science, but a complex folding pathway that proteins use to determine their shape has been harnessed by molecular biologists, enabling them to build some of the most complex synthetic ...

How to tame a restless genome

Short pieces of DNA—jumping genes—can bounce from one place to another in our genomes. When too many DNA fragments move around, cancer, infertility, and other problems can arise. Cold Spring Harbor Laboratory (CSHL) Professor ...

An international study reveals how the 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced ...

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