One of the most striking features of human genes is that genetic information required to produce proteins is stored in a discontinuous form, wherein the coding information (exons) is punctuated with non-coding segments known ...
Molecular & Computational biology
Apr 4, 2024
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10
A study at the University of Cologne's CECAD Cluster of Excellence in Aging Research has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. ...
Cell & Microbiology
Feb 2, 2024
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102
Scientists have uncovered the inner workings of one of the most important and intricate "nanobots" operating within our cells by using cutting-edge microscopy for visualizing molecules almost at an atomic level.
Cell & Microbiology
May 11, 2023
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1098
A team of scientists has created a three-dimensional map showing how a small molecule with anticancer properties—called spliceostatin—can promote the killing of cancer cells. This fundamental discovery could ultimately ...
Cell & Microbiology
May 4, 2022
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135
UCLA researchers have solved the high-resolution structure of a massive cellular machine, the spliceosome, filling the last major gap in our understanding of the RNA splicing process that was previously unclear.
Biochemistry
Nov 17, 2017
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8
RNA is the key functional component of spliceosomes, molecular machines that control how genes are expressed, report scientists from the University of Chicago online, Nov. 6 in Nature. The discovery establishes that RNA, ...
Cell & Microbiology
Nov 6, 2013
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1
A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his ...
Cell & Microbiology
Aug 21, 2013
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2
Scientists at Yale University have described in the greatest detail yet aspects of the chemical processes by which RNA carries out the expression of our genes.
Cell & Microbiology
Oct 29, 2012
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0
Making a movie at the molecular level? A new method of imaging molecule-sized machines as they do the complex work of cutting and pasting genetic information inside the nucleus is the subject of a just-published paper in ...
Cell & Microbiology
Mar 10, 2011
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0
Genes are like instructions, but with options for building more than one thing. Daniel Larson, senior investigator at the National Cancer Institute, studies this gene "splicing" process, which happens in normal cells and ...
Molecular & Computational biology
Feb 18, 2020
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5
